Otsuka Pharmaceutical Company, Limited

Takuya Minowa

Hiroshi Yamashita

Tetsuya Sato

Yusuke Hoshika

Hidekazu Toyofuku

Takayuki Nakamura

Nobuaki Ito

Yuichi Nakamura

Hideaki Kuroda

Yohji Sakurai

Masahiro Sota

Shuuji Kawano

Ryohei Eto

Takuma Ikebuchi

Kei Moriyama

Motoyuki Miyamoto

Tetsuya Yamaguchi

Tatsuya Yamaguchi

An object of the present invention is to provide a sustained-release injectable preparation which is in a medication administration form that can provide the effect of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one for a prolonged period of time, the preparation releasing a therapeutically effective amount of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one for at least one week. The present invention provides an injectable preparation containing 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or a salt thereof as an active ingredient, which releases the active ingredient in such a manner that its blood concentration is maintained for at least one week.

Injectable formulation

An object of the present invention is to provide a compound that can be used as a more superior therapeutic agent for central nervous system diseases. The present invention provides a dihydrate of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or of a salt thereof, and a process for producing the same.

Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same

Provided is a superior, novel heterocyclic compound with improved solubility in oil such as sesame oil and benzyl benzoate, which has a broader treatment spectrum, causes less side effects, and is superior in tolerability and safety, and use thereof. A heterocyclic compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof. 

Piperazine-substituted benzothiophene derivatives as antipsychotic agents

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Osaka, Japan

Takuya Minowa