Kyoto University

Hiroshi Kawamoto

Takuya Maeda

Kyoko Masuda

Yoshimoto Katsura

Provided is a method for inducing CD4CD8T cells having an antigen specific cytotoxic activity from pluripotent stem cells, comprising the steps of: (1) differentiating pluripotent stem cells to give a cell culture comprising CD4CD8T cells and CD4CD8T cells, (2) removing CD4CD8cells from the cell culture obtained in step (1), and (3) differentiating the CD4CD8cells in the cell culture into CD4CD8T cells.

Method for inducing antigen specific CD8 positive T cells

Provided is a method for inducing T cells for a cell-based immunotherapy, comprising the steps of: (1) providing human pluripotent stem cells bearing genes encoding a T cell receptor specific for a desired antigen, and (2) inducing T cells from the pluripotent stem cells of step (1). The human pluripotent stem cells bearing genes encoding the desired antigen specific T cell receptor may be prepared by introducing genes encoding the desired antigen specific T cell receptor into pluripotent stem cells.

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Kyoto, Japan

Takuya Maeda