Toyama Chemical Co., Ltd.

Takuya Kodama

Yasuyuki Suzuki

Noboru Takagawa

Yutaka Kodama

Yasuo Kiba

Hiroshi Hirano

Shiro Hirai

Isao Watanabe

Tsutomu Kodama

Masaakira Senoura

Tomonobu Yamaguchi

Norio Abe

Mikio Kawabata

Masashi Imamura

Kyoko Hongo

Katsunori Tanaka

Yukitaka Hamatani

Akira Takai

Tatsuya Miyaura

Koji Miura

Kenjun Takeshima

This invention relates to a novel N-acyl acidic amino acid diamide derivative represented by the general formula or a salt thereof: ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, represents a hydrogen atom or a substituted or unsubstituted alkyl, cycloalkyl, alkenyl or aralkyl group, or R.sup.1 and R.sup.2 and/or R.sup.3 and R.sup.4, when taken together with the respective adjacent nitrogen atoms, form a substituted or unsubstituted heterocyclic group; R.sup.5 represents a substituted or unsubstituted cycloalkyl, acyl or heterocyclic group; A represents a bond or a substituted or unsubstituted alkylene, alkenylene or alkadienylene group; and n is 1, 2 or 3. Said compound has an anti-ulcer activity which is effective to human beings and animals. This disclosure relates to such a compound, to a process for the production thereof and to an anti-ulcer agent containing the same.

N-acyl acidic amino acid diamide derivative, a salt thereof, and an

A novel 2-[4-(3-oxo- or hydroxy-alkyl)phenyl]alkanoic acid and a non-toxic salt thereof. These compounds are useful for treating symptoms of inflammation and pain in mammals including man. This disclosure relates to such compounds, a process for producing the same, a pharmaceutical composition containing such a compound, and a method for treating symptoms of inflammation and pain.

Alkanoic acid, process for its production and method of use thereof

Novel sym.-triazines having the formula: ##EQU1## wherein R.sup.1 is a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aralkyl or heterocyclic alkyl group; R.sup.2 is a hydrogen atom or a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or heterocyclic alkyl group; and Z.sup.1 and Z.sup.2, which may be the same or different, each represents oxygen or sulfur, have a central nerve inhibitory activity, an anti-inflammatory activity, an analgesic activity and a sedative activity, and can be prepared by reacting a 2,4-dichloro-6-substituted sym.-triazine with a compound having the formula HO--R.sup.2 in which R.sup.2 is the same as defined above.

Sym.-triazine carbamates

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Toyama, Japan

Takuya Kodama