Sony Corporation

Nok Corporation

Oji Holdings Corporation

Nec Corporation

Sony Computer Entertainment Inc.

Nippon Kayaku Kabushiki Kaisha

Minebea Mitsumi Inc.

Tamron Company, Ltd.

Takuya Kato

Suguru Ishikawa

Toru Koga

Kotaro Ishikawa

Takuro Kashiwamura

Kei Sasaki

Hiroyuki Kinoshita

Kenichi Nishio

Naoto Kobayashi

Atsushi Ohata

Atsuo Minato

Yuichi Tarukawa

Yuichi Shuto

Gentaro Irisawa

Shohei Yamane

Hiroki Hagiwara

Tsuyoshi Fukuda

Daisuke Kuroda

Dayong Li

Tsukasa Hashino

Go Kanzaki

Masaharu Nakamura

Mitsuru Sakamoto

Jun Nishihara

Atsushi Oohata

Atsuo Kikuchi

Ken Yamakawa

Hyongmyong Kang

A sealing apparatus includes: an annular reinforcement ring around an axis; and an annular elastic body part around the axis, which is attached to the reinforcement ring and is formed of an elastic body. The elastic body part has: a side lip, an intermediate lip, and a grease lip. A grease as a lubricant is applied to respective inner peripheral side surfaces of the side lip, the intermediate lip, and the grease lip. A thickener of the grease includes no urea-based thickener. In a usage state of the sealing apparatus, a cross sectional area of an inter-lip space enclosed by the side lip, the intermediate lip, and a hub ring is equal to or greater than 3.5 mm.

Sealing apparatus and sealing structure

The present invention provides a pentosan polysulfate having a uronic acid content of 0.0% by mass to 6.0% by mass, preferably a pentosan polysulfate having a structure represented by Formula I: wherein each R represents a hydrogen atom, &#x2014;COCHor &#x2014;SOX, and at least one R represents &#x2014;SOX, wherein X represents a hydrogen atom or a monovalent or divalent metal, and n represents an integer of 1 or more and 30 or less; a pharmaceutically acceptable salt thereof; or a pharmaceutically acceptable solvate of the pentosan polysulfate or of a pharmaceutically acceptable salt thereof. The present invention further provides a method for producing pentosan polysulfate, the method comprising the steps of depolymerizing a plant-derived raw material to obtain neutral xylooligosaccharide and sulfating the neutral xylooligosaccharide, in this order.

Pentosan polysulfate and method for producing pentosan polysulfate

The present invention provides a method for producing pentosan polysulfate, the method including a first step of obtaining an acidic xylooligosaccharide from a plant-derived raw material, and a second step of obtaining pentosan polysulfate from the acidic xylooligosaccharide. The first step includes a step of depolymerizing the plant-derived raw material. The second step includes a step of sulfating the acidic xylooligosaccharide. The method further includes a deacetylation step of adding a base to achieve a pH of 11 or higher. The deacetylation step is a step performed after the depolymerization step. The production method of the present invention can provide pentosan polysulfate having a low acetyl group content, and also produce pentosan polysulfate with a high yield inexpensively and efficiently.

Production method for pentosan polysulfate

The present invention provides a reduced-cost method for producing an acidic xylooligosaccharide, the method including a depolymerization step of depolymerizing a plant-derived raw material and a deacetylation step of adding a base to a solution of the product of the depolymerization step to achieve a pH of 11 or higher. The present invention further provides an acidic xylooligosaccharide having an acetyl group content of 0 to 5.0 mass %. The acidic xylooligosaccharide of the present invention, which has an acetyl group content of 0 to 5.0 mass %, can be used as a starting material in a production method to thereby obtain pentosan polysulfate with a high yield.

Production method for acidic xylooligosaccharide, and acidic xylooligosaccharide

The present invention provides a novel topical moisturizing preparation containing as an active ingredient at least one selected from pentosan polysulfate; pharmaceutically acceptable salts of pentosan polysulfate; and pharmaceutically acceptable solvates thereof. The topical moisturizing preparation of the present invention, which contains a substance free of animal-derived components as an active ingredient, can be produced as a topical moisturizing preparation free of animal-derived components, as needed.

Moisturizing topical preparation

The present invention provides pentosan polysulfate having a weight average molecular weight of 5000 or less and a content of acetyl groups of 0% to 2.0% by mass, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof. The pentosan polysulfate of the present invention, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof exhibits an anti-Xa activity and an anti-Xa/anti-IIa activity ratio, which are suitable for practical use, and is useful as a pharmaceutical composition such as an anticoagulant.

Pentosan polysulfate, pharmaceutical composition, and anticoagulant

A DDS preparation of a platinum complex, which exhibits a superior antitumor effect required as a medicine and reduced side effects, that is, a clinically usable DDS preparation of a platinum complex, which is conjugated to a polymer carrier that is different from conventional carriers, is desired. Provided is a polymer conjugate of a platinum(II) complex, the polymer conjugate including: a block copolymer having a polyethylene glycol structural moiety and a polyaspartic acid moiety or a polyglutamic acid moiety; a sulfoxide derivative introduced into a side-chain carboxyl group of the block copolymer; and a platinum(II) complex coordinate-bonded to a sulfoxide group of the sulfoxide derivative.

Polymer conjugate of sulfoxide derivative-coordinated platinum(II) complex

There are provided a sealing device and a hub bearing that can reduce torque. Pear-skin-like projections and depressions are provided on each of a sliding surface in a lip for foreign object (a side lipand a middle lip) and a sliding surface in a lip for grease. Roughness of the pear-skin-like projections and depressions provided on the sliding surface of the lip for greaseis larger than roughness of the pear-skin-like projections and depressions provided on the sliding surface of the lip for foreign object.

Sealing device and hub bearing

A sealing apparatus main body includes a reinforcing ring and an elastic material portion which is attached to the reinforcing ring and formed of an elastic material. The elastic material portion has a side lip formed so as to contact a slinger from the inside, a radial lip formed so as to contact the slinger from an outer periphery side, and an outer peripheral annular projection being an annular projection which is arranged on an outer periphery side of the side lip and protrudes to the outside. The slinger has a fitting portion and a flange portion extending from an outer end portion of the fitting portion to the outer periphery side. The elastic material portion forms a labyrinth seal between the outer peripheral annular projection and the side lip between the elastic material portion and the flange portion of the slinger.

Sealing apparatus

A sealing apparatus includes a sealing apparatus body that is to be attached to an outer ring of a hub bearing, and a slinger that is to be attached to a hub, in which the sealing apparatus body includes a reinforcing ring and an elastic body part. The elastic body part includes an outer periphery side labyrinth lip that is positioned on an outer periphery side of an outer periphery side end portion of the slinger and forms a gap between the hub and the outer periphery side labyrinth lip, an inner periphery side labyrinth lip, and a side lip. A distal end portion of the outer periphery side labyrinth lip is positioned on the outer side of the outer periphery side end portion of the slinger in a direction of an axis, and the outer periphery side labyrinth lip forms a groove portion in an annular shape centered about the axis and depressed toward the inner periphery side at the outer periphery side labyrinth lip on the outer periphery side.

A sealing apparatus includes a sealing apparatus body attached to an outer ring of a hub bearing, and a slinger attached to a hub, and the sealing apparatus body includes a reinforcement ring and an elastic body portion. The elastic body portion includes seal lips contacting the slinger, and a labyrinth lip forming a gap from the slinger. The slinger includes a slinger cylinder portion, a slinger flange portion, a slinger bent portion, and a slinger extended portion, and the slinger bent portion and the slinger extended portion form a labyrinth seal L, having gaps between the elastic body portion and the outer ring.

The object of the present invention is to effectively prevent the rust generation on a flange portion and to prevent the deformation of the flange portion due to the filling pressure of a molding material in the manufacture of a sealing device whereby a seal main body comprising a rubber-like elastic material and having a portion that covers both surfaces of the flange portion of a metal reinforcing ring is integrally formed on the reinforcing ring by means of a metal mold. To this end, the flange portion of the reinforcing ring is formed in advance with a shape which is distributed unevenly in the direction opposite the direction in which the flange portion is deformed from its original shape by the filling pressure of the molding material.

Method for manufacturing sealing device

A dust seal includes an annular dust seal body, an annular bushing through which a shaft is slidably inserted, and an annular seal lip provided on the bushing and slidably contacting the shaft. The dust seal body includes an annular elastic attaching portion that is fitted into an opening of a receiving portion, an annular first accordion unit having an elastic accordion, and an annular second accordion unit having an elastic accordion. The first accordion unit and the second accordion unit are arranged side by side in the direction of an axis. The first accordion unit is integral with the attaching portion, is joined to the attaching portion at an outer periphery, and is bonded to the bushing at an inner periphery by vulcanization. The second accordion unit is fixed to the attaching portion at an outer periphery, and engaged with the bushing at an inner periphery.

Dust seal

A sealing device is constructed by combination of a lip seal member attached to a not-rotating stationary member and a seal flange member attached to a rotary member. The seal lip member has a lip seal member main body having an end face lip, an outward flange portion, and an outer peripheral tube portion. The seal flange member has a seal flange member main body and an outer peripheral side tubular portion. The sealing device further includes a non-contact type labyrinth seal having a predetermined axial length arranged between the outer peripheral tube portion in the lip seal member and the outer peripheral side tubular portion in the seal flange member. The sealing device can improve sealing performance, particularly muddy water sealing performance, while fulfilling the need for low torque.

Sealing device

A zoom lens includes a first lens group having positive refractive power, a second lens group having negative refractive power, a third lens group having positive refractive power, a fourth lens group which has negative refractive power and is configured with only a single lens, and a fifth lens group having positive refractive power, which are arranged in order from an object side to an image side. During zooming, at least the first lens group, the second lens group, the third lens group, and the fourth lens group are movable in an optical axis direction. Focusing from infinity to a close range is performed by the fourth lens group being moved in the optical axis direction. At least one of following conditional expressions (1) and (2) is satisfied.&#x2212;11.0&#x3c;Fno/{(1&#x2212;&#x3b2;4)&#xd7;&#x3b2;5}&#x3c;&#x2212;7.0 and&#x2003;&#x2003;(1)&#x2212;11.0&#x3c;Fno/{(1&#x2212;&#x3b2;4)&#xd7;&#x3b2;5}&#x3c;&#x2212;7.0&#x2003;&#x2003;(2)

Growing community of inventors

Tokyo, Japan

Takuya Kato