Shiseido Company, Limited

Takuya Hiruma

Takashi Matsuda

Kouichi Nagai

Koji Kobayashi

Satoshi Amano

Masaru Suetsugu

Shinji Inomata

Hirotada Fukunishi

Tomoko Ikeda

Tetsuya Kanemaru

Shun Kubota

Kenichi Umishio

Naoto Hanyu

Shunsuke Iriyama

Ayano Matsuo

Tomo Osawa

Yukiko Sato

Katsuhiko Yagi

Ken Kusakari

Yuji Sonoyama

Yukiko Matsunaga

Mao Hitomi

Provided is an elastomer that improves the skin feel of an inorganic powder. The elastomer according to the present invention is an elastomer comprising: (A) an amino group-containing silicone polymer; and (B) a carboxyl group-containing silicone polymer or a carboxyl group-containing acrylamide polymer, wherein a molar ratio Y/X between amino groups and carboxyl groups is within a range of 0.1 to 1.2, wherein Y denotes the molar amount of carboxyl groups contained in the component (B), and X denotes the molar amount of amino groups contained in the component (A).

Elastomer

The present invention provides a method for producing a pyrimidinylpyrazole compound (1), wherein aminoguanidine (2) or its salt is reacted with a &#x3b2;-diketone compound (3) to produce the pyrimidinylpyrazole compound: 

Method for producing pyrimidinylpyrazole compounds

The present invention is benzilidene malonamide represented by the following formula (1) and salts thereof, an ultraviolet absorbent consisting of said new compound, and an external preparation containing this ultraviolet absorbent. The object of the present invention is to provide a new ultraviolet absorbent that is highly soluble in water, has superior absorption capacity over a wide ultraviolet wavelength range, has no absorption in the visible region, and is also highly stable and safe. 

Benzylidene malonamide and salt thereof, ultraviolet ray absorbent, and agent for external application to the skin

A dithiazole compound or a salt thereof is disclosed. The compound inhibits matrix metalloprotease (MMPs) activity and can be used in pharmaceutical and cosmetic compositions for the treatment of skin conditions.

Dithiazole compounds, matrix metalloprotease inhibitors and external preparations for the skin

An azabicyclo compound (I) or a salt thereof in accordance with the present invention has an excellent inhibiting action on matrix metalloproteases (MMPs) activity, and is useful for pharmaceutical, cosmetic and skin external compositions. wherein R is H, alkyl, heteroalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, acyl, COOR, carbamoyl or SOR(wherein Rand Reach are alkyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl); X is methylene, ethylene or propylene; and is a single bond or a double bond.

Azabicyclo compound matrix metalloprotease inhibitor and skin preparation

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Yokohama, Japan

Takuya Hiruma