National Cancer Center

Dainippon Sumitomo Pharma Co., Ltd.

Other

Sumitomo Chemical Company, Limited

Sii Nanotechnology Inc.

Ds Pharma Biomedical Co., Ltd.

Sumitomo Dainippon Pharma Co., Ltd.

Takumi Teratani

Takahiro Ochiya

Toshiaki Fujii

Kouji Iwasaki

Masanao Munekane

Hiroyuki Wada

Yusuke Yamamoto

The present invention provides a rat embryonic stem cell characterized by having the following properties of (a) expressing Oct3/4 gene and Nanog gene, (b) positive for alkaline phosphatase activity, (c) having an embryoid body forming ability, (d) expressing SSEA (Stage-Specific Embryonic Antigen)-1 and SSEA-4, (e) having the same number of chromosomes as does a normal rat cell, (f) capable of being subcultured and holding the undifferentiated state, (g) having in vitro pluripotency, (h) having a potential to differentiate for cells of three embryonic germ lineages, (i) having teratoma formation ability, and (j) having an ability to produce a chimeric rat, a method of establishing the aforementioned rat embryonic stem cell and the like.

Genetically modified rat derived from rat embryonic stem cell

Rat embryonic stem cell

Objects to be achieved by the invention are to provide a nanobio device in which cultured cells are organized at a high-level in a state near in vivo, and to provide a method of using the nanobio device of imitative anatomy structure. The nanobio device of imitative anatomy structure of the invention is obtained by manufacturing a substrate with a bio-compatible substance and arranging a plurality of types of cells thereon in a desired array. A method of manufacturing a nanobio device in the invention includes a step of manufacturing a substrate for a nanobio device by a micromachine processing technique and a step of arranging a plurality of cultured cells on the substrate in a desired array with laser optical tweezers.

Nanobio device of imitative anatomy structure

Growing community of inventors

Yokohama, Japan

Takumi Teratani