Teijin Limited

Meiji Seika Kaisha, Ltd.

Teijin Pharma Limited

Takumi Takeyasu

Naoki Tsuchiya

Naoki Hase

Kenichiro Kataoka

Susumu Takeuchi

Takashi Tsuruo

Hisao Yamaguchi

Tatsuki Shiota

Takao Yamori

Hirofumi Tanabe

Tsutomu Mochizuki

Mikio Ota

Atsuo Hazato

Yasuo Yamamoto

Yoshinori Kato

Takashi Kamimura

Osami Takenouchi

Masaichi Hasegawa

Koji Tomimori

Katsushi Takahashi

Sojiro Shiokawa

Tomoaki Nogata

Hidenori Kasai

Yumiko Yanagisawa

Kenzo Hariyama

Masatoshi Kano

Akihito Uemura

Disclosed is a process for producing A-form crystals of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid, comprising: a step of dissolving by heating 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid in one or a plurality of solvents as a good solvent, selected from the group consisting of 1-propanol, 2-propanol, ethanol, and acetone; a step of cooling the solution; and a step of adding to the solution a hydrocarbon solvent as a poor solvent.

Process for producing crystals of polymorphic 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecaboxylic acid by poor-solvent addition method

The present invention relates to an anthranilic acid derivative expressed by the following formula (1) or the following formula (2), or its pharmacologically permissible salt or solvate.&#x2003;

Anthranilic acid derivative

According to this invention, there is provided an indole derivative having the general formula (I)wherein A is an oxygen atom or a nitrogen atom which nitrogen atom is optionally substituted with an alkyl group, and (i) Rand Reach stand for a hydrogen atom or an alkyl group, independently, or (ii) Rand Ras taken together form a cycloalkyl group or an aromatic ring, or (iii) Rand Ras taken together form a heterocyclic ring, and Ris a hydrogen atom, a (C-C)alkyl group or others, Ris a substituted alkyl group and Ris a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group and so on, as novel compounds by a novel chemical synthetic process. The indole derivative of formula (I) exhibits a useful chymase inhibitory activity.

Indole derivatives exhibiting chymase-inhibitory activities and process for preparation thereof

The present invention relates to an anthranilic acid derivative expressed by the following formula (1) or the following formula (2), or its pharmacologically permissible salt or solvate.

Anthranilic acid derivatives

Benzene derivatives

A benzopyran derivative represented by the formula (I) or its pharmaceutically acceptable salt: ##STR1## wherein either one of X and Y stands for the following formula ##STR2## and the other one of X and Y and R.sup.1 -R.sup.10 stand for various substituents, and ACAT inhibitor, anti-hyperlipidemia agent and anti-atherosclerosis agent compositions containing the same as an active ingredient.

Benzopyran derivative, process for producing the same and pharmaceutical

Pharmaceutical compositions containing a benzoxazole compound and a 2,3-dihydrobenzofuran compound represented by the following formula (I) and its pharmaceutically acceptable salt: ##STR1## In the formula, any one of P, Q, R and S is a group represented by the formula: ##STR2## and R.sub.1, R.sub.2 and the reining three substituents out of the substituents P to S each independently stand for various substituents. These compositions are used as an ATCAT inhibitor or for treating hyperlipidemia and atherosclerosis.

Benzoxa condensed ring compounds, process for producing the same and

A naphthalene derivative having the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group or a non-toxic salt moiety; R.sup.2 and R.sup.3 independently represent a hydrogen atom or --OR.sup.4 where R.sup.4 represents a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group; A represents a group: ##STR2## [where X.sup.1 and X.sup.2 represents an oxygen atom or N--OR.sup.5 (where R.sup.5 represents a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group)], a group: ##STR3## [where Y.sup.1 and Y.sup.2 independently an oxygen atom or a group N--OR.sup.6 (where R.sup.6 represents a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group)], or a group: ##STR4## (where n is 0 or 1); and B represents --(CH.sub.2).sub.m --

Naphthalene derivatives

Growing community of inventors

Hino, Japan

Takumi Takeyasu