Yamanouchi Pharmaceutical Company Ltd.

Takumi Takahashi

Takayuki Suzuki

Tatsuya Maruyama

Kenichi Onda

Masahiko Hayakawa

Kunihiro Niigata

Tetsuo Matsui

Osamu Noshiro

Akiyoshi Shimaya

Reiko Koike

Takeshi Suzuki

Toshiyasu Mase

Kenichi Tomioka

Hiromu Hara

Hitoshi Nagaoka

Toru Kontani

Kyoichi Maeno

Toshimitsu Yamada

Takashi Yoneda

Jun Irie

An amide derivative represented by the following general formula (I) or a salt thereof and a pharmaceutical composition containing the amide derivative and a pharmaceutically acceptable vehicle.

Amide derivatives and medicinal compositions thereof

Bisoxadiazolidine derivative

##STR1## A bisheterocyclic compound represented by general formula (I), stereoisomers thereof, tautomers thereof, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof, a pharmaceutical composition containing the same, and a process for the production thereof. In formula (I), R.sup.1 and R.sup.2 may be the same or different from each other and each represents (II) or (III), R.sup.3 represents hydrogen or a protective group, X, Y.sup.1 and Y.sup.2 may be the same or different from one another and each represents oxygen or sulfur, B.sup.1 and B.sup.2 represent each phenylene, B.sup.3 represents phenylene, naphthylene, cyclohexylene or furo[3,2-b]furanylene, L.sup.1 and L.sup.2 represent each --(O).sub.n --A--, n represents 0 or 1, and A represents a single bond or lower alkylene, provided that when n is 1, A represents alkylene and the oxygen atom of each of L.sup.1 and L.sup.2 is bonded to B.sup.3. The above compounds are useful as a hypoglycemic drug based on the activity of enhancing insulin sensitivity.

Bisheterocyclic derivative or salt thereof

A saturated heterocyclic carboxamide derivative of the following general formula (I) and salts thereof which have platelet activating factor (PAF) antagonizing activity. ##STR1##

Saturated heterocyclic carboxamide derivatives

Growing community of inventors

Ushiku, Japan

Takumi Takahashi