Eisai R&d Management Co., Ltd.

Takuma Minamisono

Keigo Tanaka

Noritaka Kitazawa

Jun Niijima

Masayuki Matsukura

Kazutaka Nakamoto

Ikuo Kushida

Eiichi Yamamoto

The present invention provides a crystal of a 1.5 D-tartrate of a compound represented by the formula (1) having an A production inhibitory effect, characterized in that the crystal has a diffraction peak at a diffraction angle (20.2) of 23.2 in powder X-ray diffractometry; a crystal of a disulfate of the compound of the formula (1), characterized in that the crystal has a diffraction peak at a diffraction angle (20.2) of 17.1 in powder X-ray diffractometry; various other salts of the compound of the formula (1); crystal polymorphs of these salts; and the like, which are expected to be used as drug substances. 

Salt of tetrahydrotriazolopyridine derivative and crystal thereof

There is provided a heterocycle-substituted pyridine derivative's salt or a crystal thereof. The present invention provides an acid addition salt of 3-(3-(4-(pyridin-2-yloxymethyl)-benzyl)-isoxazol-5-yl)-pyridin-2-yl amine or a crystal thereof as well as process for producing the same.

Heterocycle-substituted pyridine derivative's salt or crystal thereof

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Tsukuba, Japan

Takuma Minamisono