Chugai Seiyaku Kabushiki Kaisha

Takuma Ikeda

Akira Kawase

Masatoshi Murakata

Keisuke Yamamoto

Nobuaki Kimura

Masahiro Nagase

Koji Takano

Tsuyoshi Haneishi

Noriaki Maruyama

Kazutomo Kinoshita

Yasuharu Kato

Noriyuki Takata

Yasushi Kitoh

Shinichi Yoshizaki

Takahiro Ichige

Mio Kobayashi

The present invention provides a process for preparing a spiroketal derivative, via an intermediate represented by Formula (VI): wherein variable groups and numbers are as defined in the specification, which can be produced from dihalobenzene derivatives in one pot reaction.

Crystal of spiroketal derivatives and process for preparation of spiroketal derivatives

The present invention provides a novel method for producing a compound represented by general formula (VII) below or a pharmaceutically acceptable salt thereof or a synthetic intermediate thereof: wherein Rrepresents a hydrogen atom or a halogen atom, Rrepresents a Calkyl group, X represents a group selected from a heteroaryl group etc., Rrepresents an atom or group selected from a hydrogen atom, a halogen atom, a Calkyl group, etc., Rand Reach independently represent an atom or group selected from a hydrogen atom, a Calkyl group, etc., and Rrepresents a hydrogen atom or a Calkyl group.

Method for producing coumarin derivative

There are provided a novel process for producing [{(5Z,7E)-(1S,3R,20S)-1,3-dihydroxy-9,10-secopregna-5,7,10(19),16-tetraen-20-yl}oxy]-N-(2,2,3,3,3-pentafluoropropyl)acetamide, which process is characterized by irradiating a compound represented by the formula: with UV to ring-open the compound, and then isomerizing the resulting compound; an intermediate useful for carrying out the process; and a process for producing the intermediate.

Process for producing vitamin D derivative using photoreaction

Growing community of inventors

Tokyo, Japan

Takuma Ikeda