The Kitasato Institute

Nagase Co., Ltd.

Pola Pharma Inc.

Takuji Nakashima

Satoshi Omura

Yoko Takahashi

Kazuro Shiomi

Masato Iwatsuki

Kazuhiko Otoguro

Atsuko Matsumoto

Yuki Inahashi

Madoka C/O Pola Chemical Industries Inc Ito

Hideaki C/O Pola Chemical Ind Inc Sasagawa

Akira C/O Pola Chemical Industries Inc Nozawa

An object of the present invention is to provide enzymes and a DNA encoding the enzymes that are involved in biosynthesis of trehangelin which has the potential to be a therapeutic agent for photosensitivity disorder and cosmetics, and to provide a method for producing trehangelin by utilizing the enzymes and a recombinant microorganism. The present invention is directed to a protein having an amino acid sequence of SEQ ID NO: 3, 5, 7 or 9, or a protein having an amino acid sequence of SEQ ID NO: 3, 5, 7 or 9 in which one to several amino acids are deleted, substituted, added and/or inserted or an amino acid sequence having 60% or more homology with the amino acid sequence of SEQ ID NO: 3, 5, 7 or 9 and having an enzyme activity involved in biosynthesis of trehangelin; and a DNA encoding said protein.

Method for producing trehangelin

The present invention addresses the problem of providing an anti-trypanosomal drug having a novel skeleton, in order to solve issues that occur with conventional technologies. The present invention is based on the discovery of a microbe that produces an anti-trypanosomal drug having a novel skeleton. Specifically, this invention provides: a compound indicated by formula (I) having a trypanosomal inhibitory activity; an analog thereof; a production method therefor; and asp. K10-0216 strain that produces said compound.

Mangromicin compound and production method therefor

Growing community of inventors

Tokyo, Japan

Takuji Nakashima