Director-general of Agency of Industrial Science and Technology

Japan As Represented by Director General of Agency of Industrial Science

Takuji Hirose

Kazuyuki Kasuga

Kazuhisa Hiratani

Hideki Sugihara

Toshikazu Takahashi

Yuichiro Himeda

Bruce Baldwin

Zhen-He Wang

Disclosed is a novel compound having activity as an ionophore for ion transport, which is a monoester or monoamide of 1,3,5-trimethyl-1,3,5-cyclohexane tricarboxylic acid, i.e. Kemp's triacid or the stereoisomer thereof, the group R in the ester group --COOR or in the amide group --CONHR being an aralkyl group or aryloxyalkyl group having 7 to 20 carbon atoms. The monoester and monoamide derivatives can be synthesized from anhydride of Kemp's triacid by subjecting the anhydride to a ring-opening esterification or amidation reaction with an alcohol or amine. On the other hand, both of the stereoisomers can be obtained by the dehydrohalogenation reaction of 1,3,5-trimethyl-1,3,5-cyclohexane tricarboxylic acid anhydride acid halide with an alcohol or amine followed by the ring-opening hydrolysis reaction on the anhydride group.

Cyclohexane tricarboxylic acid derivative and method for the preparation

A diamine derivative expressed by the following general formula (I): ##STR1## wherein R.sup.1 and R.sup.2 stand, independently from each other, for a hydrogen atom, an alkyl group, an aralkyl group or an aryl group. The diamide derivative is useful as an ionophore which can selectively transport cupric ions through liquid membranes.

.alpha.-Amino acid diamide and use thereof as cupric ion-transporting

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Tsukuba, Japan

Takuji Hirose