Astellas Pharma Gmbh

Riken Corporation

Taku Yoshida

Kanako Shimizu

Keisuke Ohsumi

Tomohiro Eguchi

Shinichiro Fujii

Masayuki Kanki

Ruriko Kado

[Problem to be Solved] Provided is an effective and safe method for treating or preventing a cancer using aAVC. [Solution] The present invention finds suitable ranges of the dose of &#x3b1;-GalCer loaded on aAVC cell surface, and the amount of &#x3b1;-GalCer loaded on aAVC cell surface in a pharmaceutical composition comprising aAVC, which are preferred in terms of securing effectiveness and safety in the treatment and prevention of a cancer using aAVC, and provides an effective and safe method for treating or preventing a cancer using aAVC, aAVC for effective and safe treatment or prevention of a cancer, and a pharmaceutical composition comprising the same, etc.

Method for treating cancer using artificial adjuvant cell (aAVC)

6-ethyl-3-({3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)pyrazine-2-carboxamide or a pharmaceutically acceptable salt thereof has an excellent immunological activation effect, and a pharmaceutical composition containing the compound or the pharmaceutically acceptable salt thereof as an active ingredient is expected to be used as a pharmaceutical composition for cancer immunotherapy and/or as a pharmaceutical composition for immunological activation.

Pharmaceutical composition for cancer immunotherapy and/or immunological activation containing diamino heterocyclic carboxamide compound as active ingredient

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Tokyo, Japan

Taku Yoshida