Daiichi Sankyo Company, Limited

Other

Ube Industries, Inc.

Sankyo Company, Limited

Taketoshi Ogawa

Fumitoshi Asai

Teruhiko Inoue

Atsuhiro Sugidachi

Naoki Tanaka

Hiroyuki Koike

Koichi Fujimoto

Yoshio Tsujita

Teiichiro Koga

Hideo Naganuma

Tatsuo Tanimoto

Naotoshi Yamamura

Kazuyoshi Nakamura

A method for the prevention of diseases caused by thrombus or embolus. The method is to separately administer 2-acetoxy-5-(&#x3b1;-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine or a pharmaceutically acceptable salt thereof, and aspirin, in their pharmacologically effective amounts, to a warm-blooded animal.

Method of treatment with coadministration of aspirin and prasugrel

A combination of 2-acetoxy-5-(&#x3b1;-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine or a pharmaceutically acceptable salt thereof, and aspirin, which possess excellent inhibitory activity against platelet aggregation and thrombogenesis, and is useful for preventing or treating diseases caused by thrombus or embolus.

Medicinal compositions containing aspirin

Acid addition salts of 2-acetoxy-5-(&agr;-cyclopropyl-carbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno&lsqb;3,2-c&rsqb;-pyridine. The acid addition salts of tetrahydrothienopyridine derivatives of the present invention exhibit excellent oral absorption, metabolization into the active compound, and platelet aggregation-inhibiting effects, low toxicity, and excellent storage and handling stabilities, and are useful as medicaments, preferably preventive or therapeutic agents (particularly therapeutic agents) for diseases caused by a thrombus or an embolus, still more preferably preventive or therapeutic agents (particularly therapeutic agents) for thrombosis or embolism.

Acid addition salts of hydropyridine derivatives

Compounds of formula (I): ##STR1## wherein: R.sup.1 represents a saturated heterocyclic group attached to the bond or group represented by A through a ring carbon atom; R.sup.2a, R.sup.2b, R.sup.2c, R.sup.3a, R.sup.3b, R.sup.3c and R.sup.3d are hydrogen or various other groups or atoms; and A represents a single bond or an alkylene group having from 1 to 6 carbon atoms are serotonin 2 receptor antagonists and have the ability to inhibit the activity of squalene synthase. They can not only prevent and inhibit the development and progression of arteriosclerosis but can also inhibit thrombosis in arteriosclerotic lesions and can improve hemodynamics.

Diphenylethane compounds containing a saturated heterocyclic group,

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Tokyo, Japan

Taketoshi Ogawa