Showa Denko K.k.

Showa Denko Kabushiki Kaisha

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Shosuke Okamoto

Taketoshi Naito

Kuniomi Marumo

Yuseki Suyama

Yoshimasa Ishimura

Hiroyuki Monzen

Tsutomu Nozawa

Motoo Miura

Kouhei Morikawa

Shuuji Hirayama

Norio Ohno

Nobuyuki Nagato

Yoshio Kimura

Yoshio Okada

Morihiko Yamada

Hiroshi Nojima

Akiko Okunomiya

Yasuhiro Katsuura

Yumi Seki

Takashi Shishikura

Katsunori Oguro

Nobuyuki Hashizume

Noble metal, particularly ruthenium, Raney catalysts which can hydrogenate (1) aromaticity-exhibiting ring portions of organic compounds, (2) carboxylic acids and their ester portions (carbonyl ester groups), (3) ring portions and carboxylic acid or their ester groups in compounds having such ring portions and carboxylic acid or their ester portions, and (4) ring portions and nitrile groups of aromatic nitrile compounds and methods for the preparation of corresponding hydrogenated compounds. The methods allow preparation of hydrogenated compounds having hydrogenated aromatic ring portions, hydrogenated carbonyl ester groups, hydrogenated aromatic ring and carbonyl ester groups, or hydrogenated aromatic rings and nitrile groups under milder hydrogen pressure and temperature conditions than the conventional catalysts.

Metal raney catalysts and preparation of hydrogenated compounds therewith

Noble metal raney catalysts and preparation of hydrogenated compounds therewith

Noble metal, particularly ruthenium, Raney catalysts having the property of catalyzing the hydrogenation of (1) aromaticity-exhibiting ring portions of organic compounds, (2) carboxylic acids and their ester portions (carbonyl ester groups), (3) ring portions and carboxylic acid or their ester groups in compounds having such ring portions and carboxylic acid or their ester portions, and (4) ring portions and nitrile groups of aromatic nitrile compounds and methods for the preparation of corresponding hydrogenated compounds. The methods allow preparation of hydrogenated compounds having hydrogenated aromatic ring portions, hydrogenated carbonyl ester groups, hydrogenated aromatic ring and carbonyl ester groups, or hydrogenated aromatic rings and nitrile groups under milder hydrogen pressure and temperature conditions than the conventional catalysts.

Noble metal Raney catalysts and preparation of hydrogenated compounds

An anti-peptic ulcer composition containing, as an active ingredient, a therapeutically effective amount of a compound having the formula (I): ##STR1## wherein A represents H.sub.2 NCH.sub.2 --, ##STR2## B represents ##STR3## D and E each independently represent H, R,--R'CO.sub.2 R,--R'(OH)CO.sub.2 R, ##STR4## wherein X represents H, CONR.sub.2, CONHR, CONH.sub.2, CO.sub.2 H, CO.sub.2 R, or COR or --R'(CO.sub.2 R)--; R' represents a lower alkylene group and R represents a lower alkyl group; F represents H, ##STR5## or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

Anti-ulcer composition

A phenylalanine derivative having the formula (I): ##STR1## where R.sup.1 and R.sup.2 are independently hydrogen provided that both R.sup.1 and R.sup.2 are not hydrogen at the same time;

Phenylalanine derivative and proteinase inhibitor

A phenylalanine derivative having the formula (I): ##STR1## wherein A represents ##STR2## B represents ##STR3## wherein m is 0, 1, or 2 and n is 3, 4, or 5; X represents (a) hydroxy, (b) nitro, (c) amino, (d) phenoxy which may be substituted with (i) halogen or (ii) nitro, (e) c.sub.1 -C.sub.4 alkyloxy which may be substituted wit (i) phenyl or (ii) benzoyl, (f) benzoyl, (g) pyridyloxy which may be substituted with (i) halogen or (ii) nitro, or (h) c.sub.1 -C.sub.4 alkyl which may by substituted with halogen;

Process for preparing an alkyl isocyanate having the isocyanate group bonded to the tertiary carbon atom of the alkyl group, which comprises reacting the corresponding alkyl halide in a substantially anhydrous condition in the presence of a specified catalyst with an alkali metal cyanate in an aprotic solvent which forms no salt with a hydrogen halide.

Process for preparing tertiary alkyl isocyanates

Process for preparing .alpha.,.alpha.-dimethylbenzyl isocyanate or its derivatives which comprises reacting the corresponding organic halide in an anhydrous condition in the presence of a specified catalyst with an alkali metal cyanate in an aprotic solvent which forms no salt with a hydrogen halide.

Process for preparing .alpha., .alpha.-dimethylbenzyl isocyanates

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Kawasaki, Japan

Taketoshi Naito