Shiseido Company, Limited

Taketoshi Kanda

Yutaka Ohtsu

Hiroshi Fukui

Kazuyuki Miyazawa

Masayoshi Wada

Osamu Shirota

Kenichi Sakuma

Motokiyo Nakano

Yousuke Toujo

Ryujiro Namba

Okitsugu Nakata

Junichi Koyama

Takashi Ogawa

Asa Kimura

Kazuhisa Ohno

Tsutomu Saito

Toshio Yoneyama

Aya Ohkubo

Kazuo Tokubo

Hideo Morohoshi

Kunihiro Kawaguchi

Yuzo Shimizu

Michihiro Yamaguchi

Kenichi Tomita

Yukimitsu Suda

Isao Tanaka

Hiroshi Kutsuna

Atsuo Sakamoto

Tomoko Kimura

Tadao Ohta

Hisao Tsuruta

Ayako Suzuki

Atsushi Kobayashi

Michio Yokouchi

Hideki Takasaki

Kenichi Tommita

Kazuko Takezawa

A method for surface modification of a material by means of introducing the phosphorylcholine group represented by the following formula (1-1) onto the surface of the material by treating a material having amino groups with a chemical compound containing an aldehyde derivative obtained by the oxidative ring-opening reaction of glycerophosphorylcholine.  The method of the present invention provides various materials such as medical materials having superior biocompatibility and hydrophilicity.

Method of modifying surface of material

A phosphorylcholine group-containing chemical compound represented by the following formula (1): 

Phosphorylcholine group-containing compound and surface modifying agent composed of such compound

A phosphorylcholine group-containing chemical compound represented by the following formula (1).  In this formula, m denotes 2-6 and n denotes 1-4. X, X, and X, independent of each other, denote a methoxy group, ethoxy group, or halogen. Up to two of X, X, and Xcan be any of the following groups: a methyl group, ethyl group, propyl group, isopropyl group, butyl group, or isobutyl group. R is one of the structures in the following formulas (2)-(4) (the chemical compound of formula (1) in the structures of the following formulas (2)-(4) is expressed as A-R&#x2014;B).  In formulas (2)-(4), L is 1-6, P is 1-3. Also a surface modifier consisting of the aforementioned phosphorylcholine group-containing chemical compound, modified powder treated with said surface modifier, a chromatography packing consisting of a modified carrier treated with said surface modifier, a filter treated with said surface modifier, and a glass device treated with said surface modifier.

Phosphorylcholine group containing compound and surface modifying agent composed of such compound

The first subject of this invention is a column packing material comprising: The second subject of this invention is a method for producing a column packing material comprising the following steps (A) to (C):

Column packing material and method for producing the same

A liquid chromatograph and a column packing material effectively condensing cationic specimen and exhibiting a high resolution. The liquid chromatograph includes a pre-focusing column ( ) having a volume of less than 2.0 milliliters and packed with a column packing material, in which a porous support is coated by a silicone polymer having a Si&mdash;R&mdash;X (R is a spacer part, X is a sulfonic group) bond and a Si&mdash;R&prime; (R&prime; is a hydrophilic group) bond, wherein the specimen to be analyzed is supplied to the pre-focusing column in the state dispersed in a solvent for condensation. The condensed specimen is then separated in a separation column ( ) used for separating the specimen dispersed in the solvent, and the separated specimen is analyzed by a detector ( ).

Liquid chromatography and column packing material

A liquid chromatograph includes pumps for supplying solvents, a mixer for mixing the solvents, a controller for controlling a mixing ratio of the solvents in the mixer, a chromatograph column for separating a sample carried with the solvents, a flow path control valve for supplying the sample together with the solvents to the chromatograph column, and a detector for detecting the sample supplied thereto, wherein the mixer includes a mixing chamber and a porous medium accommodated in the mixing chamber, the porous medium having a size and shape in conformity with a size and shape of said mixing chamber such that no substantial gap is formed between an outer surface of the porous medium and an inner surface of the mixing chamber.

Liquid chromatograph having a micro- and semi-micro column

A packing material for a column comprises a porous support coated with silicone polymer having an Si--R bond, wherein R is a hydrophobic group and an Si--R' bond, wherein R' is a hydrophilic group, and a process for the production thereof.

Packing material for column and process for production thereof

A column packing material comprising a porous support coated with a silicone polymer having an Si--R bond, wherein R is a hydrocarbon group having 1 to 18 carbon atoms, and an Si--R' bond, wherein R' is a hydrophilic group having one or more of polyoxyalkylene group or hydroxyl group at the terminal end, of which column packing material is produced by:

Column packing material with both hydrophobic and hydrophilic groups and

A modified powder or particulate material having a silicone polymer film coated on substantially the entire surface thereof, this powder or particulate material being produced by bringing at least one silicone compound, in the form of a vapor, having the general formula (I):

Modified powder or particulate material

A modified powder or particulate material coated on substantially the entire surface thereof with a film of a silicone polymer carrying a pendant group thereon, this powder or particulate material being produced by a process comprising the steps of

Modified powder

Cosmetic compositions containing modified powder or particulate material

A packing material for liquid chromatography, comprising particles having a silicone polymer film coated on substantially the entire surface thereof, the packing material being produced by a process comprising the steps of:

Packing material for liquid chromatography

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Yokohama, Japan

Taketoshi Kanda