Institute of Medicinal Molecular Design, Inc.

Shionogi Company Limited

Takeshi Yanase

Akiko Itai

Susumu Muto

Youichi Yamaguchi

Hiroshi Fukasawa

Ryuko Tokuyama

The compound represented by the following formula (I) and the like have PAI-1 inhibition activity; wherein: Rrepresents a Caryl group which may be substituted or the like; T represents a single bond or the like; m represents 0 or 1; when m is 0, G represents &#x2014;N&#x2014;C(&#x2550;O)&#x2014;COH or the like; when m is 1, G represents an oxygen atom or the like; Rrepresents a Caryl group which may be substituted or the like; E represents the following formula (II) wherein one of R, R, Rand Rrepresents the formula R-T-, each of the other three independently represents a hydrogen atom or the like, and Rrepresents the formula &#x2014;X&#x2014;Y', a hydrogen atom or the like; X represents &#x2014;CH&#x2014; or the like; Y&#x2032; represents a carboxy group or the like; M represents a single bond or the like. 

PAI-1 inhibitor

A compound represented by the following general formula (I) or a salt thereof, or a hydrate thereof or a solvate thereof having an inhibitory action against plasminogen activator inhibitor-1 (PAI-1): wherein Rrepresents a Caryl group; or a substituted Caryl group, Rrepresents a Caryl group; or a Caryl group substituted with a group or groups selected from the group consisting of a halogen atom, nitro group, a Calkyl group, a halogenated Calkyl group, a Calkoxy group, a halogenated Calkoxy group, a phenyl group and carboxy group, X represents &#x2014;CH&#x2014;, &#x2014;CHCH&#x2014;, &#x2014;CH&#x2550;CH&#x2014; or &#x2014;N(R)&#x2014;C(&#x2550;O)&#x2014;, Y represents carboxy group or a bioisostere of carboxy group, Rrepresents hydrogen atom, a Calkyl group or a Caralkyl group, m represents 0 or 1.

Carboxilic acid derivatives

Disclosed is a compound which is useful as an 11&#x3b2;-hydroxysteroid dehydrogenase type 1 inhibitor. A compound represented by the formula: 

Oxazolidinone derivative having inhibitory activity on 11&#x3b2;-hydroxysteroid dehydrogenase type 1

A compound represented by the following general formula (I) or a salt thereof, or a hydrate thereof or a solvate thereof having an inhibitory action against plasminogen activator inhibitor-1 (PAI-1): wherein Rrepresents a Caryl group; or a Caryl group substituted with a group or groups selected from the group consisting of a halogen atom, cyano group, nitro group, a Calkyl group, a halogenated Calkyl group, a Calkoxy group, a halogenated Calkoxy group and a Calkylsulfanyl group, Rrepresents a Caryl group; or a Caryl group substituted with a group or groups selected from the group consisting of a halogen atom, hydroxy group, a Calkyl group, a halogenated Calkyl group, a Calkoxy group, a halogenated Calkoxy group, a Calkylsulfanyl group and phenyl group, X represents a single bond or oxygen atom, Z represents a phenylene group or a substituted phenylene group, m represents 0 or 1.

Growing community of inventors

Tokyo, Japan

Takeshi Yanase