Takeda Pharmaceutical Company Limited

Takeshi Wakabayashi

Satoshi Yamamoto

Norihito Tokunaga

Yuya Oguro

Shigemitsu Matsumoto

Masaki Ogino

Mitsuhiro Ito

Taku Kamei

Masaki Seto

Kazuaki Takami

Masataka Murakami

Jinichi Yonemori

Tomoko Ohashi

Makoto Kamata

Masami Yamada

Eiji Kimura

Tomohiro Ohashi

Minoru Nakamura

Shinji Nakamura

Hideo Suzuki

Toshihiro Imaeda

Haruhi Ando

Tomohiro Kaku

Tomohiro Okawa

Masaki Daini

Yasutomi Asano

Hironobu Maezaki

Ayumu Sato

Satoshi Mikami

Ikuo Fujimori

Shinji Morimoto

Jumpei Aida

Kouichi Iwanaga

Shinobu Sasaki

Kenichiro Shimokawa

Makoto Fushimi

Tetsuya Tsukamoto

Yasufumi Wada

Taisuke Tawaraishi

Yasuhisa Kohara

Steve Swann

Taiichi Ohra

Yasuhiro Tsukimi

Sachie Takashima

Hiroyuki Kakei

Toshio Tanaka

Tatsuki Koike

Shinkichi Suzuki

Hiroshi Banno

Nobuyuki Takakura

Takaharu Hirayama

Shuhei Ikeda

Takuya Fujimoto

Kei Masuda

Kouji Fuji

Hirotaka Kamitani

The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the specification, or a salt thereof.

Heterocyclic compound

Provided is a heterocyclic compound that can have an antagonistic action on an NMD A receptor containing the NR2B subunit and that is expected to be useful as a prophylactic or therapeutic agent for depression, bipolar disorder, migraine, pain, peripheral symptoms of dementia and the like. A compound represented by the formula (I), wherein each symbol is as defined in the DESCRIPTION, or a salt thereof.

Heterocyclic compound and use thereof

Provided is a heterocyclic compound that can have an antagonistic action on an NMDA receptor containing the NR2B subunit, and is expected to be useful as a prophylactic or therapeutic agent for major depression, bipolar disorder, migraine, pain, peripheral symptoms of dementia and the like. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

The present invention provides a heterocyclic compound having an antagonistic action on an NMDA receptor containing the NR2B subunit, and expected to be useful as an agent for the prophylaxis or treatment of major depression, bipolar disorder, migraine, pain, behavioral and psychological symptoms of dementia and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the description, or a salt thereof.

Provided is a compound having a cholinergic muscarine M1 receptor positive allosteric modulator activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a cholinergic muscarine M1 receptor positive allosteric modulator activity, and is useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies and the like.

Aromatic ring compound

The present invention provides a compound represented by the following formula (I): wherein: Ring A represents an optionally substituted piperazine ring, an optionally substituted morpholine ring, or an optionally substituted bromopiperazine ring; Rand Rare the same or different from each other, and represent a hydrogen atom or optionally substituted lower alkyl; Rand Rare the same or different from each other, and represent a hydrogen atom or halogenated or non-halogenated lower alkyl; Rto Rare the same or different from each other, and represent a hydrogen atom, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted cycloalkyl, optionally substituted aryl, an optionally substituted aromatic heterocyclic ring, optionally substituted amino, or acyl; and represents a single bond or double bond, wherein Rand Rdo not exist when carbon atoms respectively adjacent to R: and Rform a double bond, and there is no case where all of Rto Rare hydrogen atoms, and Rand R; may form a ring together with an adjacent carbon atom; or a salt thereof. 

Benzofuran derivatives

The present invention provides a compound represented by the following formula (I): wherein:

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Kanagawa, Japan

Takeshi Wakabayashi