Fujisawa Pharmaceutical Company, Ltd.

Wakunaga Pharmaceutical Co., Ltd.

Takeshi Terasawa

Kazuo Sakane

Jiro Goto

Hideaki Yamanaka

Shinya Okuda

Yoshiki Yoshida

Masayoshi Murata

Kohji Kawabata

Hideo Tsutsumi

Akira Yazaki

Satoshi Inoue

Fumiyuki Shirai

David Barrett

Hirofumi Yamamoto

Ayako Ohki

Cephem compounds

Compounds of the formula: ##STR1## wherein R is a group of the formula: ##STR2## in which R.sup.3 and R.sup.4 are each lower alkyl or R.sup.3 and R.sup.4 are linked together to form C.sub.3 -C.sub.6 alkylene, A is lower alkylene, and R.sup.5 is hydroxy or a protected hydroxy group; or a group of the formula: ##STR3## in which R.sup.6 is lower alkyl, R.sup.7 and R.sup.8 are each hydroxy or a protected hydroxy group, and Y is N or CH, and salts thereof are intermediates for cephem compounds which show antimicrobial activities and which are useful in the treatment of microbial infections.

Intermediates for cephem compounds

Cephem compounds of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group,

Certain tricyclic pyrido[3,2,1-ij]cinnoline-8-carboxylates, useful as

Cephem compounds having the following formula are disclosed: ##STR1## R.sup.1 =amino or protected amino R.sup.2 =an organic group ##STR2## R.sup.6 =lower alkyl R.sup.7, R.sup.8 .dbd.OH or protected OH

Growing community of inventors

Ikeda, Japan

Takeshi Terasawa