The University of Tokyo

School Corporation, Azabu Veterinary Medicine Educational Institution

Keio University

Riken Corporation

Vedanta Biosciences, Inc.

School Corporation, Azabu Veterinary Medicine Educational Institute

Takeshi Tanoue

Kenya Honda

Koji Atarashi

Kikuji Itoh

Masahira Hattori

Hidetoshi Morita

Yutaka Kawakami

Hiroshi Ohno

Bernat Olle

Shinji Fukuda

Koji Hase

Satoru Morita

Ashwin Nicholas Skelly

It was found that bacteria belonging to the genusinduce accumulation of regulatory T cells (Treg cells) in the colon. Moreover, the present inventors found that regulatory T cells (Treg cells) induced by from these bacteria suppressed proliferation of effector T-cells. From these findings, the present inventors found that the use of bacteria belonging to the genusor a physiologically active substance derived therefrom made it possible to induce proliferation or accumulation of regulatory T cells (Treg cells), and further to suppress immune functions.

Composition for inducing proliferation or accumulation of regulatory T cells

Provided herein are compositions and methods for the induction and/or proliferation of CD8+ T-cells. The disclosure also provides methods of treatment of diseases that can be treated by the induction and/or proliferation of CD8+ T-cells.

Compositions and methods for the induction of CD8+ T-cells

Provided herein are methods of treating graft-versus-host disease in a subject by administering pharmaceutical compositions containing bacterial strains of the Clostridia class. Also described herein are exemplary human-derived bacteria belonging to the Clostridia class, combinations of which have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions, and are therefore useful for mitigating pathological immune responses. Pharmaceutical compositions containing these and/or related bacteria can be used to prevent and treat immune-mediated diseases such as graft-versus-host disease.

Human-derived bacteria that induce proliferation or accumulation of regulatory T cells

Species of human-derived bacteria belonging to the Clostridia class have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions. Pharmaceutical compositions containing these bacteria can be used to prevent and treat immune-mediated diseases such as autoimmune diseases.

Human-derived bacteria that induce proliferation or accumulation of

Growing community of inventors

Tokyo, Japan

Takeshi Tanoue