Mitsui Chemicals Agro, Inc.

Takeshi Takada

Yoshihisa Tsukamoto

Toshio Kaneko

Nobuhiro Kondo

Hideaki Ikishima

Hiroyuki Komai

Haruko Mita

Hidetake Yoshitomi

A method for producing a 3-(substituted oxy)-4-pyridazinol compound represented by the following general formula (I): comprising reacting a compound represented by the following general formula (III): with a compound represented by the following general formula (IV):MO&#x2014;R&#x2003;&#x2003;(IV). The compound represented by the general formula (I) can be reacted with a compound represented by the following general formula (VI): to provide a compound of general formula (V):  Each of the groups in the formulas is defined. The compounds of general formulas (I) and (V) can be obtained in a high yield and with high selectivity at a low cost, and therefore various functional and active substances can be advantageously synthesized using the compounds as a medicine, an agricultural chemical, a functional material, or an intermediate thereof.

Method for producing a 3-(substituted-oxy)-4-pyridazinol derivative

A process for producing a cyclopropylphenol represented by of formula (10): wherein R, R, Rand Reach may represent a hydrogen; Z represents a hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl or phenyl; and Y, Yand Yeach may represent a hydrogen; by reacting a compound of formula (7): wherein X represents a halogen; and V represents a hydrogen or &#x2014;W&#x2014;R,with a metal, metal salt or organometallic compound of formula (8): Mto obtain a compound of formula (9): and obtaining a compound of formula (10) by hydrolysis in the case wherein V represents &#x2014;W&#x2014;R, wherein W is CO, SO or SOand Ris alkyl, haloalkyl, cycloalkyl, alkenyl, alkynyl, phenyl, alkoxy or haloalkoxy.

Process for producing cyclopropylphenol derivative

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Omuta, Japan

Takeshi Takada