Eisai Company, Limited

Takeshi Sudo

Kazutoshi Miyake

Hitoshi Oinuma

Naoki Yoneda

Makoto Kotake

Mamoru Saito

Toshiyuki Matsuoka

Shinji Suda

Masayuki Namiki

Makoto Okita

Hideyuki Adachi

Tomohiro Matsushima

Yoshio Fukuda

Masanori Mizuno

Shigeru Souda

Kenji Hayashi

Nobuyuki Mori

The present invention relates to a substituted thiazolo[3,2-a] azepine derivative having inhibitory activity against angiotensin I converting enzyme and neutral endpeptidase and is represented by the following general formula (I): ##STR1##

Substituted thiazolo[3,2-a]azepine derivatives

Substituted thiazolo �3,2-a!azepine derivatives

The present invention relates to an amino acid derivative having an angiotensin I-converting enzyme inhibition activity, a vasopressin antagonism and an atrial natriuretic peptide hydrolase inhibition activity. This amino acid derivative is represented by the following general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or an acyl group; R.sup.2 represents a hydrogen atom, a lower alkyl group, a cycloalkyl group, an ary group which may have a substituent, a heteroaryl group which may have a substituent, an arylalkyl group which may have a substituent or a heteroarylalkyl group which may have a substituent;

Amino acid derivative

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Ibaraki, Japan

Takeshi Sudo