Daiichi Sankyo Company, Limited

Takeshi Shida

Shinji Ashida

Mitsuhiro Iwamoto

Narihiro Toda

Takahiro Katagiri

Rieko Takano

Mami Yamazaki

Koji Matsumoto

Takayuki Baba

Kazumasa Aoki

Toshio Kaneko

To find a therapeutic and/or prophylactic agent for gastrointestinal disorders and so on, the agent having excellent activity and high safety. A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof. In the formula, A represents an optionally substituted phenylene group; B represents an optionally substituted 4- to 10-membered heterocyclic group, an optionally substituted C6-C10 aryl group, or an optionally substituted C3-C10 cycloalkyl group; Rrepresents a hydrogen atom or a C1-C3 alkyl group; Rrepresents a hydrogen atom or a C1-C3 alkyl group; Rrepresents a C1-C6 alkyl group, a C3-C10 cycloalkyl group, a C1-C3 alkoxy C1-C3 alkyl group, or a C1-C3 hydroxyalkyl group; Rrepresents a hydrogen atom, a C1-C6 alkyl group, or a halogen atom; n represents an integer of 1 to 4; and X represents methylene, &#x2014;O&#x2014;, &#x2014;NH&#x2014;, &#x2014;N(C1-C3 alkyl)-, &#x2014;C(&#x2550;O)&#x2014;, &#x2014;S&#x2014;, &#x2014;S(O)&#x2014;, &#x2014;S(O)&#x2014;, or a single bond. 

Piperazinyl cyclohexane compounds as GPR38 agonists

Piperazinyl methyl phenyl cyclohexane compound

It is intended to provide a pyrimidyl indoline compound which structurally differs from compounds used as active ingredients in conventional oral hypoglycemic agents and has excellent hypoglycemic effect. The present invention provides a compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof: 

Pyrimidyl indoline compound

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Tokyo, Japan

Takeshi Shida