Ishihara Sangyo Kaisha, Ltd.

Kowa Company Limited

D. Western Therapeutics Institute, Inc.

Takeshi Ohshima

Masami Shiratsuchi

Toshiaki Oda

Masahiro Tamura

Takeo Deushi

Mitsuteru Hirata

Yoshio Takahashi

Takayoshi Ando

Hiroyuki Sonoki

Hiroshi Yoshizawa

Itaru Shigehara

Shigeyuki Nishimura

Shigeo Murai

Tadashi Nakamura

Toshio Nakajima

Norio Adachi

Akihiko Isogai

Katsuyoshi Murakami

Tetsuya Ishikawa

Takahiro Haga

Kazuhiro Onogi

Shigeru Mitani

Hiroyoshi Hidaka

Takao Awazu

Hiroshi Shimoharada

Terumasa Komyoji

Norifusa Matsuo

Hisayoshi Jonishi

Tohru Koyanagi

Ryoji Koto

Toshio Akagi

To provide a method for producing pyrimidine compound useful as an intermediate for agricultural chemicals or pharmaceuticals, which is simple in operation, presents high yield and produces only a small amount of by-products. The method comprises reacting a compound represented by the formula (I) with a compound represented by the formula (II) in the presence of a pyridine compound to produce a compound represented by the formula (III), a compound represented by the formula (IV) or their mixture. 

Method for producing pyrimidine compound

Because fluazinam is excellent as an active ingredient of pesticides and highly useful, it is desired to produce it efficiently in a proper form with simple operations at low cost in an environmentally friendly manner. The desired product is obtained in good yields with simple operations by using industrially advantageous reaction systems by a process comprising (1) a step of reacting ACTF and DCDNBTF in the presence of an alkali component, a solvent selected from the group consisting of ketones, nitriles, ethers and esters and a sufficient amount of water to substantially dissolve the alkali component, (2) a step of neutralizing or acidifying the reaction mixture with an acid and (3) a step of removing the solvent by distillation from the mixture containing fluazinam as the reaction product and the reaction solvent to precipitate crystals the product.

Process for producing toluidine compound

The present invention is directed to (S)-(&#x2212;)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1,4-homopiperazine hydrochloride dihydrate, to a method producing the dihydrate, and to a drug composition containing the dihydrate. The compound of the present invention has less hygroscopicity as compared with (S)-(&#x2212;)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1,4-homopiperazine hydrochloride anhydrous crystals and thus, exhibits excellent chemical stability.

(S)-(-)-1-(4-fluoroisoquinolin-5-Yl)Sulfonyl-2-methyl-1,4-homopiperazine hydrochloride dihydrate

A process for producing 2-phenylacetophenone derivatives represented by the formula (I):(wherein X is an alkyl group or a haloalkyl group, and Y is a hydrogen atom, a halogen atom or an alkyl group which may be substituted), which comprises reacting a compound represented by the formula (II):(wherein X and Y are as defined above, and R is a hydrogen atom or an alkyl group) with an acid.

Process for producing 2-phenylacetophenone derivatives and precursors therefor

Pyrimidine derivatives

Pyrimidine derivatives as endothelin antagonists

A novel N-phenylcarbamate compound or its salt where possible, which is useful as the active ingredient of a biocidal composition for control of harmful organisms, is represented by the following general formula (I): ##STR1## wherein R.sup.1 is unsubstituted or substituted alkyl; R.sup.2 is H, unsubstituted or substituted alkyl, alkenyl, alkynyl or cycloalkyl, or --COX.sup.1 wherein X.sup.1 is unsubstituted or substituted alkyl, alkenyl, alkynyl, cycloalkyl or alkoxy; Z is --CH.sub.2 S--, --SCH.sub.2 --, --CH.sub.2 O--, --OCH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C--, --CH.sub.2 SO--, --CH.sub.2 SO.sub.2 --, --CH.sub.2 SCH.sub.2 --, or --CH.sub.2 O--N.dbd.C(R.sup.4)--; R.sup.3 is unsubstituted or substituted phenyl, pyridyl, benzothiazolyl, benzoxazolyl, benzimidazolyl, imidazopyridyl, naphthyl, pyrimidinyl, thienyl, furyl, thiazolinyl, oxazolinyl, pyrazinyl, thiazolyl, oxazolyl, imidazolyl, pyrazolyl, quinolyl, indolyl, pyrrolyl, benzofuryl, benzothienyl, indanyl, tetrahydronaphthyl, dihydrobenzofuryl, dihydrobenzothienyl, benzoxazinyl, benzothiazinyl or benzoyl.

N-phenylcarbamate compound, process for preparing the sasme and biocidal

An imidazole compound is disclosed, which is represented by formula (I): ##STR1## wherein: X represents a --COOT group, in which T represents a hydrogen atom, an alkyl group, a benzyl group, or a phenyl group; or a --CONH.sub.2 group,

Imidazole compound and process for preparing the same

A chloronicotinic acid compound is prepared by hydrolyzing a 3-trichloromethyl pyridine compound in the presence of sulfuric acid or phosphoric acid. By this process, a highly pure chloronicotinic acid compound is obtainable in good yield. This compound is useful as an intermediate for medicines.

Process for producing chloronicotinic acid compounds

Growing community of inventors

Kusatsu, Japan

Takeshi Ohshima