Juridical Foundation the Chemo-Sero-Therapeutic Research Institute

Hisamitsu Pharmaceutical Company, Inc.

Takeshi Naruse

Hiroaki Maeda

Chikateru Nozaki

Masaki Hirashima

Takeshi Goto

Katsuhiko Akiyama

Takumi Sasaki

Wataru Hattori

A peptide fragment or a series of peptide fragments containing one or more selenocysteine that has a lowered toxicity than selenocystine and that exhibits a cytotoxicity-inhibitory activity. The peptide fragment or a series of peptide fragments according to the present invention has preferably the amino acid sequence from 260th to 362nd amino acid residues from the C-terminal of selenoprotein P, or said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences. A screening method for a peptide fragment having the cytotoxicity-inhibitory activity is also provided.

Peptide having cytotoxicity inhibitory activity and method of screening these peptide having cytotoxicity inhibitory activity

A novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, comprising as an active ingredient selenoprotein P and/or a peptide fragment or a series of peptide fragments derived from said protein is provided. The novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, according to the present invention is suitably applicable to diseases with decrease in motor function.

Method for ameliorating dyskinesia

Growing community of inventors

Kumamoto-ken, Japan

Takeshi Naruse