Daiichi Sankyo Company, Limited

Takeshi Murata

Rie Miyauchi

Shin Iimura

Masatoshi Nagamochi

Sunanda Ghosh Dastidar

Ashwani Kumar Verma

Masayuki Ishizaki

Punit Kumar Srivastava

Kumaragurubaran Nagaswamy

Lalima Sharma

Rijwan Jaffer Momin

Soma Ghosh

Pradip Balu Wagh

Sonali Nanasaheb Pansare

Balkrishna Ramchandra Kale

Pramod Raosaheb Markad

Aniruddha Mondal

Yogesh Balasaheb Khairnar

The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A' B, D, R, Rand Rare as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.

Heterocyclic compounds as protein kinase inhibitors

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Edogawa-ku, Japan

Takeshi Murata