Kabushiki Kaisha Toshiba

Chugai Seiyaku Kabushiki Kaisha

Olympus Corporation

Nichias Corporation

Basilea Pharmaceutica Ag

Takeshi Murata

Takeshi Kamigaichi

Nobuo Shimma

Satoshi Niizuma

Itaru Kawabata

Eisaku Mizuguchi

Masao Tsukazaki

Hiroshi Tanaka

Satoshi Aida

Hiroyoshi Kobayashi

Shotaro Takemoto

Takahiro Niwa

Hiroshi Fukuda

Fumitaka Arai

Satoshi Tanaka

Kosuke Kishi

Masami Kohchi

Hironobu Imanaka

Kihito Hada

Hatsuo Kawada

Hitomi Suda

Hideaki Shimada

Sousuke Hara

Masahiro Sakaitani

Hitoshi Iikura

Yoshiaki Isshiki

Yasunori Kohchi

Yoshito Nakanishi

Masanori Miwa

Kazunao Masubuchi

Yasuaki Matsubara

Shinya Wasada

Takehiro Okada

Fumio Watanabe

Junya Fujita

Katsumi Watanabe

Shinji Tsujii

Kosuke Aso

Manabu Yasuda

Kenichi Kawasaki

Makoto Mizukami

Fumiki Aiso

Takeshi Sonehara

Susumu Komiyama

Nobuaki Yasutake

Hiroyuki Nitta

Hiroaki Ohkuma

Yutaka Ishibashi

Jun Nishimura

Takuo Tsukuda

Tadakatsu Hayase

Miyako Masubuchi

Toshiyuki Mio

Michio Fujino

Masahiro Aoki

Masayuki Sudoh

Shunichi Searashi

Yutaka Miyata

Takahide Watanabe

Mieko Yanagisawa

Yuri Yasuda

Saku Hashiura

Futoshi Tanaka

Jun Wakasone

A medical device includes an insertion unit; and a drive unit, the insertion unit has first, second and third lumens, the drive unit has first and second pulleys disposed to be movable advance and retraction, first and second wires are wound on the first and second pulleys, respectively, and a pulling mechanism to pull the first and second pulleys toward a proximal end side, the first wire has a first end inserted into the first lumen and fixed to a distal end side of the insertion unit and a second end inserted into the second lumen and fixed to the distal end side of the insertion unit, and the second wire has a first end inserted into the third lumen and fixed to the distal end side of the insertion unit and a second end fixed to the drive unit.

Medical device and treatment system

A surgical system includes: an overtube including a channel into which an endoscope is inserted; and an expansion device configured to ensure a surgical space by expanding an interior of a body at a distal side relative to a tip of the overtube. The expansion device includes a sheath and a wire configured to be protrudable from the sheath. The wire is configured to be switchable between a first configuration in which the wire protrudes from the sheath and a second configuration in which the wire protrudes from the sheath in a state where the wire is tilted, around a longitudinal axis, at an angle different from the first configuration.

Surgical system and expansion device

A multi-layered metal sheet is disclosed formed of a laminate of a plurality of metal sheets fixed to each other by a clinch formed in a concave shape from one main surface toward another main surface, the clinch has an schematic pillar shape, the clinch being defined by an open top, a pair of cut surfaces which are respectively formed from the open top toward a bottom, a pair of inclined surfaces respectively inclined from the open top toward the bottom, transitional surfaces which connect the cut surfaces and the inclined surfaces to each other, and the bottom having overlapping parts which extend over the main surface of the multi-layered metal sheet on a lower side immediately below the cut surfaces, and lengthwise end portions of a cut formed in each of upper edge portions of the cut surfaces are disposed on upper edge portions of the transitional surfaces.

Multi-layered metal sheet

A medical overtube device has a main body formed by articulating a plurality of nested units into a first group of nested units and a second group of nested units and is bendable in a longitudinal direction thereof; a first shape-fixation mechanism configured to fix a shape of the first group which has a first wire, both end of the first wire coupled to the first group of nested units and a first pulley configured to be wound by the first wire; and a second shape-fixation mechanism configured to fix a shape of the second group which has a second wire, both end of the second wire coupled to the second group of nested units; and a second pulley configured to be wound by the second wire, wherein the first shape-fixation mechanism is configured to release the fixed shape of the first group independently from the second shape-fixation mechanism.

Medical overtube device

A medical device insertion method includes: inserting an endoscope into an overtube until a distal end of the endoscope protrudes from a distal end of the overtube; grasping a part of the endoscope protruding from the distal end of the overtube and inserting the endoscope into the large intestine until the distal end of the endoscope is between the splenic flexure and the sigmoid colon of the large intestine; and inserting the overtube together with the endoscope into the large intestine until the distal end of the endoscope is beyond the splenic flexure while grasping the overtube from an outer radial direction so as to deform the overtube in an inner radial direction until an inner surface of the overtube is pressed against an outer circumferential surface of the endoscope, and then inserting the overtube into the large intestine until a reinforced region is placed in the splenic flexure.

Medical device insertion method

Provided is a joint mechanism including two spur gears and; a support member that supports the two spur gears and so as to be rotatable about two joint shafts and that are disposed in a skew-lines positional relationship with a space between each other; and a rotational-force transmitting mechanism that transmits a rotational force between the spur gears and, wherein the rotational-force transmitting mechanism is provided with a transmission member formed of a rigid piece that is supported so as to be movable only in a direction parallel to a line of intersection between planes and that are respectively orthogonal to the two joint shafts and cam mechanisms or linkage mechanisms that are disposed between the transmission member and the two spur gears and, respectively, and that convert rotational motions of the spur gears and to a linear motion of the transmission member.

Joint mechanism and medical equipment

The present invention relates to quinazolinone and isoquinolinone derivatives represented by formula (I) or pharmaceutically acceptable salts thereof. 

Quinazolinone and isoquinolinone derivative

The present invention relates to benzamide derivatives represented by formula (I) or pharmaceutically acceptable salts thereof. 

Benzamide derivative

The present invention relates to quinazolinedione derivatives represented by formula (I) or pharmaceutically acceptable salts thereof. 

Quinazolinedione derivative

A cylinder head gasket includes two main members on two sides, and middle members sandwiched therebetween. The middle members are composed of a first middle member and a second middle member that is separated and distinct therefrom. The first middle member is a metal plate that has cylinder hole rim portions encircling cylinder holes to a particular width, with beads surrounding the cylinder holes being formed in the cylinder hole rim portions. The metal plate either forms separated items, one at each cylinder hole, or else forms an integrated item connected between the cylinder holes. The second middle member is a metal plate that is disposed on the outside of the first middle member and has oil holes and bolt holes. The thickness of the first middle member is greater than that of the second middle member.

Cylinder head gasket

A nonvolatile semiconductor memory includes a cell unit having a select gate transistor and a memory cell connected in series, a select gate line connected to the select gate transistor, and a word line connected to the memory cell. One end of the word line is bent to the select gate line side, and a fringe is connected between a bent point and a distal end of the word line.

Nonvolatile semiconductor memory having a word line bent towards a select gate line side

According to one embodiment, a plurality of memory cell transistors including a floating gate and a control gate and a plurality of peripheral circuit transistors including a lower electrode portion and an upper electrode portion are included. The floating gate includes a first polysilicon region, and the lower electrode includes a second polysilicon region. The first polysilicon region is a p-type semiconductor in which boron is doped, and the second polysilicon region is an n-type semiconductor in which phosphorus and boron are doped.

Nonvolatile semiconductor memory device and manufacturing method thereof

A gasket held between opposite flange joint surfaces with a bolt includes a combination of a complex material with a rubber material formed on one or both sides of a steel plate, the complex material having a convex or waveform bead, and a circular metal plate arranged at a bolt portion with a through-hole where a shank of the bolt penetrates and a bearing corresponding portion that corresponds to a bearing of the bolt around the through-hole. The gasket is configured to have the thickness (H) of the bead provided to the complex material greater than the thickness (H) of the circular metal plate that is equal to or greater than the thickness (H) of the complex material. This structure provides a gasket indicating good sealing properties under such circumstances that a flange has low stiffness, a tightening load is reduced, and the distance between bolts is expanded.

Gasket

Growing community of inventors

Yokohama, Japan

Takeshi Murata