Daiichi Sankyo Company, Limited

Nippon Telegraph and Telephone Corporation

Tdk Corporation

Sumco Corporation

Honda Motor Co., Ltd.

Mitsubishi Denki Kabushiki Kaisha

Bridgestone Corporation

Sankyo Company, Limited

Sumitomo Bakelite Company Limited

National Space Development Agency of Japan

Kobe Gakuin Educational Foundation

Parker Industries, Inc.

Sony Corporation

Sony Group Corporation

Takeshi Masuda

Takashi Nakada

Shinji Ashida

Hideki Miyazaki

Hiroyuki Naito

Masao Yoshida

Yuji Kasuya

Yuki Abe

Yusuke Ogitani

Koji Morita

Ichiro Hayakawa

Sayaka Yagi

Yuki Urabe

Taeko Tsubokura

Mitsuhiro Iwamoto

Hiroaki Uchida

Yusuke Ota

Narihiro Toda

Daisuke Okajima

Hidetaka Koya

Makoto Komiyama

Hideki Nakamura

Satoshi Tanaka

Tetsuya Takahashi

Kimio Tsuchikawa

Fumihiro Yokose

Kensuke Nakamura

Hirofumi Hamada

Tomoko Terauchi

Masaki Meguro

Fuminao Doi

Naoya Harada

Hajime Nakajima

Taku Murase

Akira Kataoka

Chikara Ishizaka

Toshihiro Kuroshima

Fumihiko Kimura

Fumitaka Baba

Haruo Oishi

Takeshi Nomura

Makoto Iwasaki

Takeshi Honda

Makoto Koizumi

Akira Inoue

Takahiro Imai

Yoshinori Fujikawa

Akira Sato

Tetsuya Hidaka

Yasushi Enokido

Kentaro Ito

Yoshihiko Minachi

Yukie Nakano

Yoshiyuki Onishi

Masafumi Matsuo

Takuma Hayakawa

Syota Goto

Hidenobu Umeda

Koji Mitake

Noboru Ito

Junichi Nagaoka

Masami Arai

Munemitsu Hamada

Kenya Takagawa

Haruna Nakajima

Haruo Taguchi

Yoshio Tange

Hiroshi Kuga

Shinnosuke Tsuji

Hikaru Okubo

Kazuo Igarashi

Masashi Tadokoro

Akira Takeishi

Ayato Kakoki

Yoshiyuki Tanaka

Yukiko Sekiguchi

Yoichiro Inaba

Kaori Masumiya

Ikuko Takagi

Akihiko Shimizu

Nagatoshi Nawa

Yoshiyuki Kobayashi

Satoru Yasuda

Kazuhisa Iwanaga

Shunsuke Kurasawa

Takahide Maeda

Toshiya Nishino

Noriharu Tanaka

Kazuhiko Maesori

Makoto Yamashita

Koki Nakanishi

Yuto Kawabata

Kiyotaka Akasaka

Norimi Ashimoto

Kenichi Nishikawa

Kiyotaka Yashiro

Hiroyuki Adachi

Tadashi Shiraishi

Yuji Miyachi

Yasutoshi Yamaguchi

A protein that recognizes a drug moiety of an antibody-drug conjugate in which a drug represented by the following formula is conjugated to an antibody via a linker, and a method for quantifying the concentration in plasma of an antibody-drug conjugate in a mammal to which the antibody-drug conjugate has been administered, by using the protein, and a method for identifying a tissue distribution of an antibody-drug conjugate.

Protein recognizing drug moiety of antibody-drug conjugate

The present invention provides a novel antibody-pyrrolodiazepine derivative and a novel antibody-pyrrolodiazepine derivative conjugate using the same, and a novel CLDN6 and/or CLDN9 antibody.

Methods of treating a tumor by administering a claudin-6 (CLDN6) or CLDN9 antibody-pyrrolobenzodiazepine derivative conjugate

Provided are novel antibody-pyrrolodiazepine derivative and novel antibody-pyrrolodiazepine derivative conjugates, as well as methods of using the same, and a novel CLDN6 and/or CLDN9 antibody. The disclosed compounds are of the class of alkyl benzene sulfonyl ureas, useful as oral anti-diabetics, and include substituted benzo[e]pyrrolo[1,2-α][1,4]diazepine.

Antibody-drug conjugates comprising substituted benzo[e]pyrrolo[1,2-a][1,4]diazepines

As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L-L-L-NH—(CH)n-L-L-L- wherein the antibody is connected to the terminal of L, and the antitumor compound is connected to the terminal of Lwith the nitrogen atom of the amino group at position 1 as a connecting position.

Antibody-drug conjugate

An operation log acquisition device includes processing circuitry configured to store a determination image that is an image of a characteristic area of an operation screen that is used to perform a predetermined operation, an event occurrence area in which an event may occur when the predetermined operation is performed, operation type specifying information that specifies an operation type, and an acquisition image area that is to be acquired when the predetermined operation is performed, in association with each other, upon detecting an occurrence of the event, acquire an occurrence time of the event, an occurrence position of the event, and a captured image of the operation screen, and determine whether or not the captured image acquired includes a matching area that the determination image matches, and acquire an event occurrence area of the determination image if the captured image includes the matching area.

Operation logs acquiring device, operation logs acquiring method, and operation logs acquiring program

A management device obtains a first operational process, which is an operational process described in an operational procedure manual for an application, and a second operational process, which is an operational process performed by a user on the application. The management device further determines whether the first operational process is consistent with the second operational process or not. If the management device determines that the first operational process is not consistent with the second operational process, the management device displays a review screen to check inconsistency between the operational processes.

Management device, management method, and management program

A debug information abstraction unit () of a proxy server () adds, when a predetermined rule of an extension program is embodied into a program, a program for outputting debug information regarding the predetermined rule to the embodied program. Then, a debug information transmission unit () of a terminal device () transmits, to a debug support device (), the debug information regarding the predetermined rule for which the program has been added.

Debugging assistance system and debugging assistance method

A display control device has display setting information including setting information of a layer structure of display objects on a terminal screen and setting information of a group to which the display objects belong, display state information indicating a display state of the display object, and operation setting information defining which setting content a combination of an operation target and operation content on a screen indicate for a layer structure and a group of display objects for each combination of the operation target and the operation content. The display control device specifies the setting content to the display object based on the combination of the operation target and the operation content, the display state information, and the operation setting information when an operation on the display object occurs. The display control device generates the display state information in which the layer structure of the display objects or the group to which the display objects belong is changed, based on the display setting information and the specified setting content and displays a screen.

Display control device, display control method, and display control program

The present invention establishes a molecular therapy for glycogen storage disease type Ia. The present invention provides an oligonucleotide of 15-30 bases comprising a nucleotide sequence complementary to die cDNA of G6PC gene with c.648G>T mutation, wherein the oligonucleotide comprises a sequence complementary to a region comprising any site between the 82to the 92nucleotide from the 5′ end of exon 5 of the G6PC gene with c.648C>T mutation, a pharmacologically acceptable salt or solvate thereof. Also provided is a pharmaceutical drug comprising the oligonucleotide, a pharmacologically acceptable salt or solvate thereof (e.g., therapeutic drug for glycogen storage disease type Ia).

Therapeutic agent for glycogen storage disease type IA

An acquisition unit acquires image data by performing screen capture of a screen operated by a user, at a predetermined interval. A detection unit detects the user operation. An estimation unit estimates an amount of delay time from a user operation time point to a time point at which the user operation is detected by the detection unit. The selection unit selects image data of the user operation time point out of the acquired image data.

User operation recording device and user operation recording method

A peripheral information acquisition unit () acquires information relating to a first application () running in a terminal, information relating to control of the terminal, or information that can be acquired from a sensor included in the terminal, as peripheral information. The peripheral information acquired by the peripheral information acquisition unit () is accumulated in a peripheral information accumulation unit (). A dialogue interface unit () accepts input of information from a user and outputs information to the user. When the peripheral information accumulated in the peripheral information accumulation unit () and information input to the dialogue interface unit () satisfy a predetermined condition, a scenario control unit () causes the dialogue interface unit () to output information relating to execution of a second application () that is associated with the condition in advance.

Operation support system, operation support method, and operation support program

A magnet structure includes a first sintered magnet, a second sintered magnet, and an intermediate layer disposed between the first sintered magnet and the second sintered magnet. Each of the first sintered magnet and the second sintered magnet independently includes crystal grains containing a rare earth element, a transition metal element, and boron. The intermediate layer contains rare earth element oxide phases and crystal grains containing a rare earth element, transition metal element, and boron. Each of the transition metal elements independently includes Fe or a combination of Fe and Co. An average coverage factor of the rare earth element oxide phases measured on the basis of a cross section perpendicular to the intermediate layer of the magnet structure is within a range of 10% to 69%.

Magnet structure

A display control device acquires event data, that is, data expressed as a set of fixed units of data, and uses the acquired event data to display an image of the event data visualized according to a predetermined visualization method. Additionally, in the case of receiving an operation of attaching an electronic label to the displayed image, the display control device stores information about the electronic label, the event data, and setting information related to the image when the electronic label was attached in association with each other in storage. Also, in the case of receiving the specification of an electronic label to be restored from among the electronic labels, the display control device acquires the data of the electronic label as well as the event data and setting information associated with the electronic label from the storage, and restores the image with the electronic label attached.

Display control device and display control method for displaying images including electronic labels

As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L-L-L-NH&#x2014;(CH)n-L-(CH)n-C(&#x2550;O)&#x2014; wherein the anti-HER2 antibody is connected to the terminal L, and the antitumor compound is connected to the carbonyl group of the &#x2014;(CH)n-C(&#x2550;O)&#x2014; moiety with the nitrogen atom of the amino group at position 1 as the connecting position

Method for treating cancer comprising administration of anti-HER2 antibody-drug conjugate

A timeline display device includes processing circuitry configured to store event data for displaying a figure that represents an operation along a time axis, the event data including a start time point and an end time point of the operation, acquire a search condition that specifies an appearance pattern of the figure that is displayed, and search for data pieces of the event data that match the acquired search condition.

Timeline display device, timeline display method and timeline display program

Growing community of inventors

Tokyo, Japan

Takeshi Masuda