Kyowa Hakko Kogyo Co., Ltd.

Takeshi Kuroda

Fumio Suzuki

Kenji Ohmori

Shigeto Kitamura

Haruhiko Manabe

Hiroaki Hayashi

Yoshikazu Miwa

Kazuhiro Kubo

Hiroshi Nakajima

Takashi Kawakita

Akira Karasawa

Akio Ishii

Junichi Shimada

Yoshisuke Nakasato

Tatsuya Tamaoki

Shunji Ichikawa

Tetsuji Ohno

Katsuichi Shuto

Ichiro Miki

Toshikazu Kamiya

Tadafumi Tamura

Junichi Ikeda

Hisashi Hosoe

Yoshisuke Nakazato

Disclosed are imidazonaphthyridine derivatives represented by formula (I) ##STR1## wherein: R.sup.1 represents lower alkyl or substituted or unsubstituted aryl; and

Imidazonaphthyridine derivatives

Thienoimidazoppyridone derivatives

Quinoline derivative having serotonin-3 receptor antagonizing activity

Disclosed is a pyrazolonaphthyridine compound represented by the formula: ##STR1## wherein R.sup.1 is represents hydrogen, lower alkyl, aralkyl, or substituted or unsubstituted aryl, R.sup.2 represents hydrogen, lower alkyl, thienyl, substituted or unsubsutituted aryl, hydroxy or amino, or a pharmaceutically acceptable salt thereof. The compound possesses antiinflammatory effect, immunosuppressive effect, broncho-dilatory effect and hair growth-stimulative effect.

Condensed naphthyridine derivatives

There are disclosed condensed purine derivatives represented by formula; ##STR1## in which R.sup.3 represents hydrogen, lower alkyl or benzyl; each of X.sup.1 and X.sup.2 independently represents hydrogen, lower alkyl, aralkyl or phenyl; and n is an integer of 0 or 1; R.sup.1 represents hydrogen, lower alkyl, alicyclic alkyl, noradamantan-3-yl, dicyclopropylmethyl or styryl; and R.sup.2 represents hydrogen, lower alkyl or alicyclic alkyl; or a pharmaceutically acceptable salt thereof. The derivatives and pharmaceutically acceptable salts are useful as diuretics, renal protecting agents, antiallergic agents and hypotensives.

Condensed purine derivatives

Disclosed is a thienopyridine derivative represented by formula (I): ##STR1## wherein one of A and B represents --S-- and the other represents --CH.dbd.; R represents hydrogen or lower alkyl, and Z represents pyridyl; or a pharmaceutically acceptable salt thereof. The thienopyridine derivative is useful as an immunoregulator and for the prevention and treatment of osteoporosis.

Thienopyridine derivatives

Disclosed are naphthyridine derivatives represented by formula (I) ##STR1## wherein: X represents hydrogen; lower alkyl; aralkyl; substituted or unsubstituted aryl; substituted or unsubstituted aromatic heterocyclic group; --NR.sup.1 R.sup.2 wherein R.sup.1 and R.sup.2 independently represent hydrogen or lower alkyl; ##STR2## wherein W represents N or CH, Z represents a single bond, oxygen or NR.sup.3 (wherein R.sup.3 represents hydrogen, lower alkyl or benzyl) and n1 and n2 represent an integer of 1 to 3; or substituted or unsubstituted thiazolinyl; and

Anti-inflammatory 1,8-naphthyridin-2-one derivatives

Disclosed is a hexitol derivative represented by the formula (I): ##STR1## wherein Q represents a formula selected from the group consisting of ##STR2## wherein a represents NH, O or S;

Hexitol derivatives having vasodilative activity

Novel imidazoquinolone derivative represented by formula (I); ##STR1## wherein R.sup.1 represents lower alkyl or --(CH.sub.2).sub.m CO--R.sup.3 where R.sup.3 represents hydrogen, lower alkyl, hydroxy or lower alkoxy; and m is an integer of 1 to 3; R.sup.2 represents lower alkyl; or a pharmaceutically acceptable salt thereof.

Imidazoquinolone derivatives

Novel imidazoquinolone derivative represented by the formula (I); ##STR1## wherein R.sup.1 represents hydrogen, alkyl, cycloalkyl, alkenyl aralkyl, aralkenyl or substituted or unsubstituted aryl; X represents nitrogen or ##STR2## where R.sup.2 is hydrogen, hydroxyl, alkyl, cycloalkyl, alkenyl, aralkyl, aralkenyl, substituted or unsubstituted aryl, thiol, halogen, substituted or unsubstituted aromatic heterocyclic group, or --(CH.sub.2).sub.m CO.sub.2 R.sup.6 where R.sup.6 is hydrogen or lower alkyl and m is an integer of 0 to 3; Y represents oxygen or sulfur; R.sup.3 represents alkyl, cycloalkyl, alkoxyalkly, alkenyl, aralkyl, aralkenyl, --(CH.sub.2).sub.n -- Het where Het is substituted or unsubstituted aromatic heterocyclic group and n is an integer of 1 to 3 or --(CH.sub.2).sub.n CO.sub.2 R.sup.6a where n has the same meaning as defined above and R.sup.6a has the same meaning as defined as to R.sup.6 ; each of R.sup.4 and R.sup.5 independently represents hydrogen, lower alkyl, trifluoromethyl, cycloalkyl, halogen, hydroxyl, lower alkoxyl, lower alkylthio, nitro, amino, lower alkylamino, lower alkanoylamino, aroylamino, lower alkanoyl or aroyl; and a pharmaceutically acceptable salt thereof. The Compound (I) and a pharmaceutically acceptable salt thereof show bronchodilatory and antiallergic activities, and are useful for treating respiratory disorders such as bronchial asthma.

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Shizuoka, Japan

Takeshi Kuroda