Bridgestone Corporation

Sankyo Company, Limited

Nippon Steel Sumitomo Metal Corporation

Takeshi Kinoshita

Koichi Morita

Tatsuo Haneishi

Masatoshi Inukai

Yoshinori Egashira

Takatsugu Hashimoto

Toshihiro Yotsumoto

Kiyoshi Hamano

Takashi Fujita

Takao Yoshioka

Takuya Hara

Keiko Shimizu

Yoshiharu Sakaida

Fujio Isono

Yoshiyuki Kumamoto

Hiroyoshi Horikoshi

Mutsuo Nakajima

Tomohisa Nishikawa

Shuji Takahashi

Masaaki Miyamoto

Kouhei Furuya

Tsutomu Kanai

Takeshi Kagasaki

Hideyuki Haruyama

Ryuzo Enokita

Kazuhiko Tanzawa

Kazuaki Tanaka

Osamu Ando

Kanichi Nakamura

Kunihiro Sasahara

Akira Sato

Yasuyuki Takamatsu

Toshihiko Yotsumoto

A polyester copolymer having an aromatic amine incorporated in the main chain, which is excelent in thermal stability as well as dynamic property, and a process for the production of the polyester copolymer, whereby the existing installation of the prior art can be used as it is, thus resulting in lowering of the production cost, are provided. The polyester copolymer comprises an aromatic dicarboxylic acid, diol and at least one compound selected from the group consisting of aromatic compounds having amino group, represented by the following general formula (I),

Polyester copolymer and a process for the production of the same

5-Amino-1-(hydroxymethyl)cyclopentane-1,2,3,4-tetraol and 2-amino-4-(hydroxymethyl)-3a,5,6,6a-tetrahydro-4H-cyclopent[d]oxazole-4,5, 6-triol, which have the ability to inhibit the activity of sugar hydrolases, especially .beta.-glucosidase and sucrase and can thus be used for the treatment and prophylaxis of tumorous conditions, AIDS, diabetes and obesity, can be prepared by hydrolysis of trehazolin. 2-Amino-4-(hydroxymethyl)-3a,5,6,6a-tetrahydro-4H-cyclopent[d]oxazole-4,5, 6-triol can also be prepared by fermentation using newly isolated strains Micromonospora sp. SANK 62390, FERM BP-3521 and Amycolatopsis sp. SANK 60791, FERM BP-3513.

Polyhydroxycyclopentane derivatives, their preparation and their

The process for producing mureidomycin A, B, C or D or a salt thereof by cultivating Streptomyces flavidovirens SANK 60486, FERM BP-1347, in a culture medium therefor and isolating mureidomycin A, B, C or D or a salt thereof from the cultured broth.

Fermentation process for preparing antibiotics mureidomycins A, B, C and

Solid golf balls comprise a vulcanizable rubber and a reinforcing filler comprising an essentially anhydrous metal salt of an .alpha.,.beta.-ethylenically unsaturated carboxylic acid. Golf balls containing such reinforcing fillers have improved physical properties over rubber compounds containing conventional metal carboxylic acid salts. Additionally, the rubber compounds have improved processability and shorter curing time.

Solid golf balls reinforced with anhydrous metal salts of

Compounds of formula (I): ##STR1## in which: A is a group of formula (II) or (III): ##STR2## W is methylene, carbonyl or &gt;C.dbd.N--OV, where V is hydrogen, sulfo, acyl or alkyl; U is methylene, or W is absent and U is a carbon-carbon double bond between A and --CR.sup.1 (OH)--; R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each hydrogen or alkyl; Y.sup.1 and Y.sup.2 are each hydrogen or a hydroxy-protecting group; and n is 1, 2 or 3 and salts thereof have anti-diabetic activity in mammals. Methods of preparing them are also provided.

Thiazolidine derivatives with anti-diabetic activity, their preparation

A new compound, which we have named 'Leualacin' has the formula (I): ##STR1## and may be prepared by cultivation of a microorganism of the genus Hapsidospora, especially Hapsidospora irregularis. The compound may be used for the treatment and prophylaxis of cardiovascular diseases and disorders, especially hypertension.

Compound 'Leualacin', its preparation and its use in the treatment of

Solid golf balls are produced by the method comprising the steps of preparing a polymer cement in a suitable organic solvent, forming a suspension of the metal salt of an .alpha.,.beta.-ethylenically unsaturated carboxylic acid in a suitable aliphatic hydrocarbon solvent miscible with the organic solvent, mixing the polymer cement and the suspension together, removing the solvents to provide the metal salt uniformly dispersed within the polymer, and thereafter manufacturing a solid golf ball therefrom. Solid golf balls comprise a vulcanizable rubber and from about 5 to 100 parts by weight of a reinforcing filler comprising a metal salt of an .alpha.,.beta.-ethylenically unsaturated carboxylic acid, per 100 parts of the vulcanizable rubber. When the metal salts are incorporated via solution masterbatching, the resulting golf balls have improved physical properties.

Solid golf balls reinforced with metal salts of

A novel adhesive composition capable of bonding strongly polyester fibers and rubbers with reduced adhesive deterioration even at high temperatures is provided which comprises, as a predominant component, a co-condensation resin obtained by co-condensing at least one member selected from compounds (I) represented by the following general formula, ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen atoms, alkyl groups or alkoxy groups, the sum of carbon atoms of R.sub.1 and R.sub.2 being 0 to 4, at least one member selected from compounds (II) represented by the following general formula, ##STR2## wherein R.sub.3, R.sub.4 and R.sub.5 are hydrogen atoms or alkyl groups, the sum of carbon atoms of R.sub.3, R.sub.4 and R.sub.5 being 0 to 4, and aldehyde.

Adhesive composition for fibrous materials based on

New antibiotics of the mureidomycin group have the formula ##STR1## wherein X represents the group ##STR2## and wherein R represents hydrogen, an alkyl group having from 1 to 10 carbon atoms, an alkenyl group having from 2 to 7 carbon atoms, an alkynyl group having from 3 to 7 carbon atoms, an aryl group having from 6 to 10 carbon atoms, an aralkyl group having from 7 to 10 carbon atoms, or one of the said aryl or aralkyl groups substituted with at least one substituent selected from halogen and alkyl groups having from 1 to 5 carbon atoms. The compound in which X represents 8-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl is named mureidomycin E and the compound in which X represents 6-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl is named mureidomycin F. This group of compounds and their pharmaceutically acceptable esters and salts are useful as antibiotics for the treatment of bacterial infections. Mureidomycins E and F can be obtained by fermentation of a suitable Streptomyces strain, in particular Streptomyces flaviodovirens SANK 60486 (BIKOKEN JOHKI 1347; FERM BP-1347). Alternatively, all of the compounds can be obtained synthetically by reacting the previously known compound mureidomycin A with an aldehyde of the formula

Antibiotics of the mureidomycin group, their preparation, and their

An aniline-resorcin-formaldehyde copolycondensation product having a particular mol ratio of aniline to resorcin is used in an adhesive composition for well adhering fibrous material to rubber.

Aniline-resorcin-formaldehyde copolycondensation product

Novel compounds, called mureidomycins A, B, C and D, may be prepared by cultivation of a suitable microorganism of the genus Streptomyces, especially Streptomyces flavidovirens SANK 60486 (FERM P-8636, FERM BP-1347). These represent a wholly new class of antibiotics, which are valuable in the treatment of infections caused by a variety of bacteria, notably of the genus Pseudomonas.

Antibiotics called 'mureidomycins A, B, C, and D' and their therapeutic

Rubber compositions excellent in adhesion to metals, particularly suitable for steel cord coating rubbers, having a high vulcanizing rate and little offensive smell in an unvulcanized state, which comprise 100 parts by weight of a rubber and 0.01-1 part by weight as a cobalt element content of at least one cobalt oxyketone complex represented by the following general formula: ##STR1## wherein R.sub.5 -R.sub.14 are same or different, hydrogen atom, C.sub.1 -C.sub.18 alkyl, C.sub.5 -C.sub.12 cycloalkyl, C.sub.6 -C.sub.14 aryl, C.sub.6 -C.sub.14 aryl-C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.18 alkoxyl, C.sub.5 -C.sub.12 cycloalkoxyl, C.sub.6 -C.sub.14 aryloxyl, C.sub.6 -C.sub.14 aryl-C.sub.1 -C.sub.4 alkoxyl groups, or C.sub.2 -C.sub.18 hydrocarbon groups having at least one double bond.

Rubber compositions

Rubber compositions excellent in adhesion to metals, particularly suitable for steel cord coating rubbers, having a high vulcanizing rate and little offensive smell in an unvulcanized state, which comprise 100 parts by weight of a rubber and 0.01.about.1 part by weight as a cobalt element content of at least one cobalt oxyketone complex represented by the following general formula: ##STR1## wherein R.sub.1 .about.R.sub.4 are same or different C.sub.1.about.18 alkyl, C.sub.5.about.12 cycloalkyl, C.sub.6.about.14 aryl-C.sub.1.about.4 alkyl, C.sub.1.about.18 alkoxyl, C.sub.5.about.12 cycloalkoxyl, C.sub.6.about.14 aryloxyl, C.sub.6.about.14 aryl-C.sub.1.about.4 alkoxyl groups, or C.sub.2.about.18 hydrocarbon groups having at least one double bond.

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Tokyo, Japan

Takeshi Kinoshita