Hokko Chemical Industry Co., Ltd.

Takeshi Kawarabayashi

Teruhiko Terakawa

Hisakazu Hasegawa

Mikio Shoji

Atsushi Takahashi

Masao Ishimoto

Shigeru Utsumi

Yasushi Shimada

Shigeru (deceased) Utsumi

A transformed soybean plant having a gene encoding a modified seed storage protein introduced therein, obtained by inserting a gene encoding an Alzheimer's disease vaccine to a variable region(s) of a gene encoding a wild-type seed storage protein, is produced, and said vaccine is produced and accumulated in the seeds thereof.

Transformed soybean plant which accumulates vaccine, and use thereof

A vaccine composition for prophylaxis and/or therapy of Alzheimer's disease, which comprises a fusion protein prepared by inserting a single or tandemly repeated multiple copies of amyloid &#x3b2; antigenic peptide having 5 to 15 continuous amino acid residues derived from the N-terminus of amyloid &#x3b2; peptide into a wild type seed storage protein.

Vaccine composition for prophylaxis and/or therapy of Alzheimer's disease

Growing community of inventors

Hirosaki, Japan

Takeshi Kawarabayashi