Sankyo Company, Limited

Takeshi Kagasaki

Shuji Takahashi

Hideyuki Shiozawa

Kentaro Kodama

Akira Ishii

Yoshio Tsujita

Tomowo Kobayashi

Yukio Sugimura

Kimio Iino

Takafumi Kohama

Isao Kaneko

Keiichi Matsuda

Ryuzo Enokita

Hideyuki Haruyama

Takemichi Nakamura

Yoko Shimada

Takeshi Kinoshita

Akio Torikata

Masaaki Miyamoto

Kouhei Furuya

Koichi Hirai

Kiyoshi Hamano

Yuji Iwano

Kazuhiko Tanzawa

Yoshiharu Sakaida

Kaneo Ogawa

Katsumi Fujimoto

Radicicol derivatives in which one or both hydroxy groups are acylated have valuable anti-tumor activity or may be used as chemical intermediates.

Radicicol derivatives, their preparation and their anti-tumor activity

A compound of the formula ##STR1## in which: R.sup.1 and R.sup.2 are independently selected from the group consisting of hydrogen atoms and groups of formula R.sup.3 --CO--, wherein R.sup.3 represents a group selected from the group consisting of unsubstituted alkyl groups having from 9 to 20 carbon atoms; substituted alkyl groups having from 10 to 20 carbon atoms; unsubstituted alkenyl groups having from 9 to 20 carbon atoms; substituted alkenyl group having from 10 to 20 carbon atoms; unsubstituted alkynyl groups having from 8 to 10 carbon atoms; and substituted alkynyl groups having from 8 to 10 carbon atoms wherein R.sup.1 and R.sup.2 are not both hydrogen atoms or acetyl groups. The compounds have antitumor activity.

New compounds, which we have named the 'Leustroducsins' have the formula (I): ##STR1## in which R represents a 5-methylhexanoyloxy group, a 6-methyloctanoyloxy group or a 7-methyloctanoyloxy group, and salts thereof, and may be prepared by fermentation using a microorganism of the genus Streptomyces, especially a strain of the species Streptomyces platensis, such as strain SANK 60191 (FERM BP-3288). These compounds may be used for the treatment or prophylaxis of: adverse reactions resulting from cancer chemotherapy or radiotherapy; infections; cancer; cerebral dysfunction; and fungal infections.

Process to prepare leustroducsins

The present invention relates to a novel antibacterial compound obtainable from the genus Alteromonas and which shares structural similarity with the pseudomonic acids.

Culture of alteromonas and process of using the same to produce an

Two thiomarinol derivatives, which have antibacterial and anti-mycoplasmal properties, are obtainable from microorganisms of the genus Alteromonas and are named 'thiomarinol B' and 'thiomarinol C'. Thiomarinol B can also be prepared by the oxidation of thiomarinol.

Thiomarinol compounds

Compounds, named the 'Leustroducsins', their preparation and their

Anti-bacterial compound and pharmaceutical compositions thereof

A new compound, which we have named 'Leualacin' has the formula (I): ##STR1## and may be prepared by cultivation of a microorganism of the genus Hapsidospora, especially Hapsidospora irregularis. The compound may be used for the treatment and prophylaxis of cardiovascular diseases and disorders, especially hypertension.

Compound 'Leualacin', its preparation and its use in the treatment of

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Iwaki, Japan

Takeshi Kagasaki