Matsushita Electric Industrial Co., Ltd.

Nippon Sheet Glass Company, Limited

Seikagaku Corporation

Panasonic Corporation

Seikagaku Kogyo Kabushiki Kaisha

Takeshi Ishimaru

Katsumi Kozu

Kenji Senda

Masatoshi Izaki

Koichi Toriyama

Satoshi Kataoka

Hiroyuki Tanaka

Hidemitsu Takeuchi

Tomihisa Saito

Yoshinori Iwaizono

Iichiro Mori

Shoji Konishi

Masahiro Mizuta

Katsuyuki Shirasawa

Kiyoshi Suzuki

Koji Yamamoto

Takashi Kishimoto

Shigeru Kajiwara

Yoshiki Osawa

Tatsuhisa Chikada

Masaru Kawabe

Hiroyuki Nemoto

Makoto Ikeda

Takashi Fukuzawa

Kenjin Masumoto

Shuichi Miyaura

Yeong Shik Kim

Hirohiko Iwase

Yasuhiro Ogawa

Koichiro Nakamura

Shigeo Kittaka

Hiroyuki Masuda

Takahiro Hashimoto

Hiroshi Fujita

Akimitsu Sato

Yasuhiro Kurahashi

Hiroaki Imanishi

Minoru Taniyama

Junichi Onaya

Masaaki Kaneda

Sawako Takeshita

Shigeyuki Wakitani

Hideki Azuma

Toshio Yamashitafuji

Ikuto Ohyama

Shinji Ota

The inventions provides a method for immunologically determining a keratan sulfate level which method includes bringing an anti-keratan sulfate monoclonal antibody into contact with a biological sample, the anti-keratan sulfate monoclonal antibody exhibiting a relative reaction specificity between keratan sulfate-I and keratan sulfate-II represented by IC50of 0.4 to 5, to thereby provide a signal; and detecting keratan sulfate contained in the biological sample from the signal. On the basis of the method, the invention also provides a joint disease detection method and a method for assessing the effect of a remedy for a joint disease and a candidate substance therefor. Through these methods, a very small amount of keratan sulfate contained in a sample, can be determined. Particularly, these methods can determine, at high-sensitivity and high-specificity, the total keratan sulfate including keratan sulfate-I, which have been difficult to determine through a conventional technique. The methods also enables detect a joint disease and assess the effect of a remedy for a joint disease or a candidate substance therefor.

Method for assaying keratan sulfate, assay kit therefor and method for detecting joint disease by using the same

An antibody that reacts with 2-O-desulfated acharan sulfate, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The antibody that reacts with 2-O-desulfated acharan sulfate can be produced by immunizing a mammal using as an antigen a substance obtained by chemically bonding a protein to 2-O-desulfated acharan sulfate.

Anti-2-O-desulfated acharan sulfate antibody and its application

A heat insulation sheet () covers a temperature fuse () arranged on a sealing plate () of a rechargeable battery () so as to provide a shield from heat of resin that is filled in a gap between the rechargeable battery () and a circuit substrate () to form a primary mold () and to prevent destruction of the temperature fuse () caused by the heat.

Method for manufacturing battery pack

A rod- or plate-shaped light guide includes a first end that receives illuminating light incident thereon, a bottom surface having a reflecting portion thereon for reflecting the light, an emitting face which emits the reflected light, and a protruding portion protruding longitudinally and continuously from the light guide at a second end thereof. The protruding portion has a reduced peripheral dimension compared to a peripheral dimension of an adjacent portion of the light guide, and a reflective body is provided on the protruding portion and covers a longitudinal end face of the protruding portion extending perpendicular to the emitting face. When viewed along an axial direction of the light guide, the reflective body does not jut out from an end face of the light guide even when the body wraps on to a side surface of the protruding portion or expansion occurs.

Light guide having reflective protruding portion, and lighting devices including such light guide

A rechargeable battery () and a circuit substrate () are connected by lead plates () and united by a primary mold () that is formed by filling resin therebetween, after which a secondary mold () is formed on the outer face by filling resin at necessary locations and a winding sheet () is wound around the periphery, thereby forming a battery pack.

Method for manufacturing a battery pack

An anti-acharan sulfate antibody, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The anti-acharan sulfate antibody can be produced by immunizing a mammal using as an antigen a substance obtained by chemically bonding a protein to acharan sulfate.

Anti-acharan sulfate antibody and its application

An antibody which reacts with N-acetylheparosan and heparan sulfate that is derived from bovine kidney but does not substantially react with heparan sulfate derived from a murine Engelbreath-Holm-Swarn tumor tissue, the antibody being produced with a hybridoma which is prepared using a substance composed of a protein and N-acetylheparosan bound to the protein.

Anti-heparan sulfate antibody, method for detection of heparan sulfate, and kit for detection of heparan sulfate

A rod-shaped light guide which does not cause unevenness in color at the portion near an incident face is produced by injection-molding transparent resin such as acryl and its surfaces include a light-emitting surface, a bottom face, left and right sides and end faces. One end face opposes a light emitting unit, and light scattering patterns for scattering light incident from the end face are formed on the bottom face. The light scattering patterns are different in shape between a portion near the end face as the incident face and a portion away from the end face. The light scattering patterns formed at the portion near the incident face are composed of a large number of fine hemispherical concaves, whereas the light scattering patterns at the portion away from the incident face are composed of triangular grooves or half cylindrical grooves, and the axial direction of these triangular grooves or half cylindrical grooves coincides with the width direction (sub-scanning direction) of the bottom face on which the patterns are formed.

Light guide having light scattering patterns with different light reflected directions

A circuit substrate () being electrically connected to a rechargeable battery () is arranged upon a sealing plate () with a gap therebetween and united with the rechargeable battery () by filling resin in the gap. A primary mold () formed by the resin is firmly retained by undercut portions formed in engaging protrusions (). The engaging protrusions () may be formed by welding separate engaging members ().

Battery and method of manufacturing the battery

A structure of a line lighting device permits a rod-like light guide to be attached to a case without rubbing against the case. An end portion of the rod-like light guide provided with a pin is inserted into an opening in a case main body and pushed down, thus making the pin engage with a recess in the case main body. At this time, a distal end of the rod-like light guide is inserted, to some extent, into an opening in a light emitting unit fixing portion. Subsequently, the rod-like light guide is pushed down and pivoted around the pin so as to be completely contained within the case main body. In this state, the distal end of the rod-like light guide is fitted into the opening and the end face of the rod-like light guide is flush with the outer side face of the light emitting unit fixing portion.

Line lighting device and image reading device

A battery pack () includes: a battery (); a circuit substrate () having a charge/discharge safety circuit and arranged on one end face () of the battery; and an end case () in which an external connection terminal () is set. In this battery pack, the circuit substrate () is arranged inside the end case (), and the end case () is secured to the battery by screws () with a screw head () extending through and engaging with the end case () at both ends and tips of the screw () being engaged into the end face () at both ends of the battery (). This achieves a compact battery pack with a reduced connection resistance, while achieving both high reliability and productivity.

Battery pack

An improved illumination device shortens a redundant area of insufficient light intensity close to a longitudinal end thereof. The device includes a casing, a bar-shaped light guide housed in the casing to cause a light-emitting surface thereof to be exposed, a light-emitting unit secured to an end section of the casing, wherein light from the light-emitting unit is introduced into the bar-shaped light guide through the end face thereof and is totally reflected within the bar-shaped light guide to be emitted through the light-emitting surface, and a shielding section provided to cover an end section of the bar-shaped light guide including the redundant area at the end section of the casing close to the light-emitting unit. A notch is formed at the end section of the bar-shaped light guide on the light-emitting surface side close to the light-emitting unit, and light from the light-emitting unit is reflected on a rear surface of the shielding section through a gap between this notch and the light-emitting unit to be introduced into the bar-shaped light guide.

Illumination device and image scanning device

The present invention provides a safe and novel stabilizing agent for enzymes; a composition containing an enzyme and the stabilizing agent; and a kit containing the stabilizing agent composition. According to the invention, deactivation or inactivation of the activity of the enzyme during storage, drying, freezing, etc. can be prevented, without raising any problem of potential infection of an enzyme with a pathogen. For purposes of the invention, the stabilizing agent for an enzyme contains a plant-derived polypeptide as an active ingredient.

Stabilizing agent for enzymes

Battery pack having circuit substrate resin molded to battery

Constructing a battery pack by: providing a resin sheet () to cover a release opening () of a safety vent () formed on a sealing plate (); integrating a rechargeable battery () and a circuit substrate () with a primary molding () by filing a resin between the rechargeable battery () and the circuit substrate (); and then forming a secondary molding (). In such constructed battery pack, an ejected gas, at the operation of the safety vent () of the battery pack, is externally released through an interface between the resin and metal.

Battery pack with resin integrated substrate and vent

Growing community of inventors

Moriguchi, Japan

Takeshi Ishimaru