Other

Takeshi Hom-ma

Takaya Sato

Nagayoshi Myo

Hironobu Nanbu

The present inventors have made studies for the purpose of establishing a process for preparing controlled-release preparations which can rapidly release 99% or more of a slightly soluble medicament (which has by itself shows a slow dissolution rate) in the upper part of the small intestine. As a result, the inventors have succeeded in establishing a process comprising carrying a slightly soluble medicament which has a slow intestinal dissolution rate on aggregates of the spherical microparticles of a multivalent metal alginate, in which each of the secondary particles (i.e., the aggregates) has a specific surface area ranging from 1 to 280 m,/g. This success leads to the accomplishment of the present invention.

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Tokyo, Japan

Takeshi Hom-ma