Kaneka Corporation

Kanegafuchi Kagaku Kogyo Kabushiki Kaisha

Gc Corporation

Natl. Inst. of Adv. Ind. Science & Tech.

Takeshi Fukuchi

Fumio Osakada

Kenji Yamashita

Keiji Matsumoto

Masamichi Takagi

Hideo Niwa

Satoru Yokomizo

Akinori Ohta

Masao Sato

Tetsu Kakutani

Akiko Nishi

Tadashi Kaneko

Hajime Ohgushi

Takaaki Ohara

Tomoko Nishino

Tadahiro Edamura

Koji Hattori

Ichiro Shimizu

Kota Uematsu

The present invention provides a scaffold in which cells can be stably retained and grafted in a uniform distribution state in the culture, preferable proliferation ability and viability can be secured, and particularly in the case of cartilage, fixation treatment such as suture can be carried out in the transplantation into affected parts after the culture, and the mechanical strength is provided sustainable for (weighted) compression at the initial stage of transplantation. The present invention relates to a 3-dimensional porous scaffold for tissue regeneration Further, the invention relates to the above 3-dimensional porous scaffold in which seeding properties of cells are improved by a pore enlargement treatment of one side face by a separation operation, a salt elution operation of a surface part, or a combination of these operations. It becomes possible to produce a 3-dimensional cell combination having excellent degree of tissue formation and medical treatment effect by seeding a cell or precursor cell derived from a tissue in this scaffold, and culturing them in an artificial environment and/or the living body.

Support for tissue regeneration and process for producing the same

This invention relates to a method of producing polyesters resulting from homopolymerization or copolymerization of a 3-hydroxyalkanoic acid(s) and having biodegradability and good physical properties using yeasts as hosts. By constructing at least one enzyme gene involved in polyester synthesis by adding a DNA coding a peroxisome-targeting signal, introducing an enzyme gene expression cassette containing that gene into yeast, and cultivating the thus-obtained transformant, it becomes possible to cause accumulation of a polyester resulting from homopolymerization or copolymerization of a 3-hydroxyalkanoic acid(s) in yeast cells and recover the polyester from the culture.

Enzyme gene participating in the synthesis of polyester and process for producing polyester using the same

The present invention relates to a gene coding for a copolyester-synthesizing enzyme, a microorganism which utilizes the gene for the fermentative synthesis of a polyester, and a method of producing a polyester with the aid of the microorganism. More particularly, the present invention relates to a gene which functions in a host organism and, by an enzyme, synthesizes a plastic-like polymer degradable under the action of microorganisms in the natural environment (the soil, river or sea). The present invention also, more particularly, relates to a transformant derived from the host organism by transformation with the gene and having an improved ability to fermentatively synthesize a plastic-like polymer, and a method of producing a copolyester with the aid of the transformant.

Transformant and process for producing polyester by using the same

The present invention provides a method for inducing immunosuppressive cells by cultivating human cells with the use of a culture device having an affinity for protein and the culture device to be used therefor. According to the present invention, immunosuppressive cells can be efficiently induced by using a solid culture and can provide an efficient therapeutic system for diseases caused by hypersensitivity of the immune system with less side effect.

Method for inducing immunosuppressive cells and a culture device to be used therefor

A sheep LFA-3 protein and derivertires thereof, and derivertives of a human LFA-3 protein, gene coding for the proteins, and processes for preparing the proteins. Said proteins have high affinity for human T-cells.

Cell adhesion protein, gene coding for the same, process for preparing

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Akashi, Japan

Takeshi Fukuchi