Shionogi Company Limited

Takeshi Endoh

Hiroyuki Kai

Yukio Tada

Tsuyoshi Hasegawa

Takayuki Kameyama

Miho Oohara

Yoshiyuki Taoda

Masaaki Uenaka

Kyozo Kawata

Masahiko Nagai

Takuya Shintani

Akira Iida

Hiroyuki Tobinaga

Yasuhiko Fujii

Tohru Horiguchi

Kentaro Asahi

Sae Jikihara

Toshikatsu Maki

Ken'ichiroh Nakamura

The present invention provides a novel P2Xand/or P2Xreceptor antagonist. A compound represented by the formula (I): wherein R, Rand Rare,

Triazine derivative and pharmaceutical composition comprising the same

The present invention provides novel compounds having a P2Xand/or P2Xreceptor antagonistic effect. A pharmaceutical composition having a P2Xand/or P2Xreceptor antagonistic effect comprising a compound of the formula (I): wherein

Heterocyclic derivative and pharmaceutical composition comprising the same

The present invention provides a novel P2Xand/or P2Xreceptor antagonist. A compound represented by the formula (I): 

The present invention provides a novel P2Xand/or P2X/receptor antagonist. A compound represented by the formula (I): wherein Zis optionally protected hydroxy, etc.; Zis &#x2014;C(&#x2550;O)&#x2014;, etc.; Zand Zare taken together &#x2550;O or &#x2550;S; t is an integer of 0 to 4; Rand Rare each independently, hydrogen or substituted or unsubstituted lower alkyl, etc.; m and n are each independently an integer of 0 to 2; k is an integer of 0 or 1; Ring A is an aromatic carbocyclic ring or a heterocyclic ring, etc.; B is aromatic carbocyclic ring-diyl or heterocyclic ring-diyl, etc.; Rand Rare each independently halogen, hydroxy, substituted or unsubstituted lower alkyl, etc.; Ris substituted or unsubstituted alkyl, etc.; Ris substituted or unsubstituted alkyl, substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group, etc.; or its pharmaceutically acceptable salt, or a solvate thereof is provided.

Pyrolinone derivative and pharmaceutical composition comprising the same

Industrial and commercial processes for the preparation of 2-acyl-5-benzylfuran derivatives, 1,2,4-triazole-3-carboxylic acid ester derivatives or propenone derivatives having an anti-HIV activity; and useful crystals of the derivatives. A deblocking: (III-2), (IV-10), (VI-1), wherein R , R and R are each independently hydrogen or the like; A is CR or N; R is hydrogen or the like; Q is a protecting group; and L is a leaving group.

Processes for the preparation of substituted propenone derivatives

Growing community of inventors

Osaka, Japan

Takeshi Endoh