Chugai Seiyaku Kabushiki Kaisha

Tokyo Ohka Kogyo Co., Ltd.

Osaka University

Takeshi Baba

Noriyuki Takahashi

Yasuo Suzuki

Takashi Ohsaka

Tomoyuki Igawa

Hiroyuki Tsunoda

Atsuhiko Maeda

Junichi Nezu

Atsushi Kumanogoh

Yuri Teranishi

Ryusuke Omiya

Sachiyo Suzuki

Toshiyuki Ogata

Naoka Hironiwa

Shinya Ishii

Yoshinao Ruike

Shun Shimizu

Takehisa Kitazawa

Takuya Noguchi

Shigero Tamba

Miho Funaki

An objective of the invention is to provide an antibody, a composition for use in detecting or capturing a polypeptide in a sample, and a method for detecting or capturing a polypeptide in sample. The disclosure provides an antibody, a composition for use in detecting or capturing a polypeptide in a sample, and a method for detecting or capturing a polypeptide in sample.

Antibodies, compositions for use in detecting or capturing a polypeptide in a sample, and methods for detecting or capturing a polypeptide in a sample

An objective of the present invention is to provide methods for promoting antigen uptake into cells by antigen-binding molecules, methods for increasing the number of times of antigen binding by one antigen-binding molecule, methods for promoting reduction of the antigen concentration in plasma by administering antigen-binding molecules, and methods for improving the plasma retention of an antigen-binding molecule, as well as antigen-binding molecules that allow enhanced antigen uptake into cells, antigen-binding molecules having an increased number of times of antigen binding, antigen-binding molecules that can promote reduction of the antigen concentration in plasma when administered, antigen-binding molecules with improved plasma retention, pharmaceutical compositions comprising the above antigen-binding molecules, and methods for producing them. The present inventors revealed that the above objective can be achieved by using antigen-binding molecules that show calcium-dependent antigen-antibody reaction.

Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly

The present inventors newly discovered that even if an antigen-binding molecule inhibits in vitro some of the physiological activities of an antigen having two or more physiological activities without inhibiting the remaining physiological activities, the molecule can promote elimination of the antigen from blood (from serum or plasma) and as a result reduce the physiological activities in vivo, when the antigen-binding molecule is conferred with the properties: (i) of binding to human FcRn under an acidic pH range condition; (ii) of binding under a neutral pH range condition to human Fc receptor stronger than native human IgG, and (iii) that its antigen-binding activity alters according to the ion concentration.

Methods for producing antibodies promoting disappearance of antigens having plurality of biological activities

Provided is a novel anti-Plexin-A1 agonist antibody that promotes dendritic cell contraction. Also provided is a pharmaceutical composition comprising such an antibody and a pharmaceutically acceptable carrier.

AntiPlexin A1 agonist antibody

In an aspect, the present invention provides a structure, a structure-manufacturing method, a cell-sorting method, or the like. In an aspect, a structure () of the present invention is a structure including a first substrate () and a second substrate () disposed to face one side of the first substrate (), in which the first substrate () has a plurality of depressions () which are open to the other side of the first substrate and each of which has a size that enables each of the depressions to capture one unit of a cell, at least some of the depressions () have communication holes () which communicate with one side and the other side of the first substrate and each of which has a size that enables secretions secreted from the cell to move through the communication holes, the second substrate () can include accumulation portions () in which the secretions moving through the communication holes () are accumulated, and the accumulation portions () can correspond to the depressions ().

Substrate, structure, structure-manufacturing method, cell-sorting method, cell-manufacturing method, and secretion-producing method

Container for cell observation

Growing community of inventors

Shizuoka, Japan

Takeshi Baba