Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo

Takeshi Ario

Masashi Kurimoto

Madoka Taniai

Kozo Yamamoto

Shigeharu Fukuda

Kakuji Torigoe

Toshio Miyake

Takashi Shibuya

The object of the present invention is to provide a composition which exerts a higher effect on recovering health from articular disorders than that attained by amino sugars and glycosaminoglycans. The present invention solves the object by providing an agent for treating articular disorders, comprising an amino sugar and trehalose as effective ingredients.

Drugs against articular failure

Disclosed are polypeptides which originate from mammal, having L-asparaginase activity. The polypeptides are easily prepared by applying recombinant DNA techniques to DNAs encoding the polypeptides and they exert satisfactory effects in the treatment and/or the prevention for diseases caused by tumor cells dependent on L-asparagine, and cause no substantial serious side effects even when administered to humans in relatively-high dose.

Polypeptides having L-asparaginase activity

Disclosed is a DNA coding for mammalian L-asparaginase. Transformants introduced with the DNA effectively produce desired amounts of mammalian L-asparaginase such as those from humans, guinea pigs, and mice. The DNA is also useful as a probe for screening a DNA coding for desired mammalian L-asparaginase.

DNA coding for mammalian L-asparaginase

A composition which comprises a flavonoid and a processed product of a plant of the genus Pfaffia. The composition effectively maintains and promotes the health, treats and prevents diseases, and exerts immunoenhancement, antiallergic, psychotropic, and/or tonic activities.

Growing community of inventors

Okayama, Japan

Takeshi Ario