Ajinomoto Co., Ltd.

Takeru Sato

Kenzo Yokozeki

Kenji Fujiwara

Toshihide Yukawa

Yoshiteru Hirose

Chiaki Sano

Kiyohiko Nishi

Tetsuo Tanegawa

Eiji Majima

Hiroshi Kaneko

Hirofumi Tasaki

Masaki Koga

Seisaku Furuya

Testuo Tanegawa

The present invention provides a method of manufacturing a highly pure ammonium succinate solution including the steps of (A) producing calcium succinate trihydrate by crystallization fermentation of a microorganism; (B) converting calcium succinate trihydrate to calcium succinate monohydrate by transition crystallization; (C) separating the calcium succinate monohydrate crystals; (D) substituting the calcium salt in the calcium succinate monohydrate with ammonium salt resulting in an ammonium succinate solution; and (E) removing the solid calcium carbonate from the ammonium succinate solution.

Method of manufacturing succinic acid and ammonium succinate solutions

A method of obtaining optically active anhydrous phenylalanine crystals from an aqueous solution containing optically active phenylalanine, which involves crystallizing and precipitating optically active phenylalanine from an optically active phenylalanine super-saturated solution at a temperature, T, wherein the super-saturated solution is required to have an osmotic pressure .pi. (mOsm/kg.H.sub.2 O) which is related to said temperature T in accordance with the following formula (I):

Method of obtaining anhydrous phenylalanine crystals

A process for producing L-aspartyl-L-phenylalanine alkyl or aryl esters wherein L-aspartic acid and L-phenylalanine which is esterified with an alkyl group having at least two carbon atoms, an aryl group or an aralkyl group, are contacted in an aqueous medium with particular microorganisms or enzyme fractions from these microorganisms and the condensed product crystallizes out due to insolubility in the aqueous medium.

Process for the production of L-aspartyl-L-phenylalanine esters

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Saga, Japan

Takeru Sato