Johns Hopkins University

Takeru Igusa

James Kevin Guest

Sen Lin

Antony Rosen

Livia Angela Casciola-Rosen

Marikki Laiho

Ami A Shah

Marikki K Laiho

This document relates to materials and methods for assessing and/or treating subjects (e.g., subjects having autoimmune diseases). For example, materials and methods for determining if a subject (e.g., a human having an autoimmune disease) has one or more antibodies that can be used to identify the subject as having a lower risk of cancer or as having a higher risk of cancer are provided. Materials and methods for treating a subject (e.g., a human) identified as having a higher cancer risk for cancer are also provided.

Materials and methods for assessing cancer risk and treating cancer

The present invention is directed to an improved fluid diode using topology optimization with Finite Element Method (FEM). Topology optimization as a flexible optimization method has been extended to the fluid field. For given boundary conditions and constraints, it distributes a specific amount of pores (or remove materials to get channel) in the design domain to minimize/maximize an objective function. In this design, inlet and outlet ports are aligned and inflow and outflow are in the same direction. The present invention features an intricate network of fluid channels having optimized fluid connectivity and shapes, which significantly improves the diodicity of fluidic passive valves.

Passive diode-like device for fluids

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Baltimore, MD, United States of America

Takeru Igusa