Alza Corporation

Merck + Co., Inc.

Interx Research Corporation

Oread Laboratories, Inc.

Iprx, Inc.

University of Kansas

Takeru Higuchi

Anwar A Hussain

Nicolae S Bodor

John W Shell

Toshiaki Nishihata

John L Haslam

Arthur R Mlodozeniec

Jose Alexander

Yu-Neng Kuo

Harold M Leeper

Stefano A Pogany

Richard S Givens

Howard J Rytting

Osborne S Wong

Robert G Carlson

Gordon L Amidon

Arnold J Repta

Kenneth J Himmelstein

Colin R Gardner

Robyn C Cargill

Larry J Caldwell

Kasturi Srinivasachar

Jennifer B Dressman

Efraim Shek

David W Bourne

Siegfried Lindenbaum

Anand C Burman

Pramod M Kotwal

Takao Kawasaki

Masahiro Nakano

Bodgan Matuszewski

The invention relates to pyroglutamic acid esters used as dermal penetration enhancers for therapeutic agents having poor skin permeation.

Pyroglutamic acid esters used as dermal penetration enhancers for drugs

Provided is a novel barrier membrane and a method using the barrier membrane for testing the transdermal penetration behavior of a bioactive agent. The method employs shed snake skin as the model barrier membrane. In particular, the method comprises the steps of providing a dose of a donor formulation containing the bioactive agent, and a receptor solution, with a barrier membrane of shed snake skin separating the donor formulation and receptor solution. The receptor solution is then serially sampled and assayed in order to determine the concentration of the bioactive agent in the receptor solution. The use of the shed snake skin has been found to provide reproducible and uniform results as a model barrier membrane. As well, the shed snake skin offers the advantages of being readily available and storable for an extended period of time.

Method for in vitro determination of transdermal absorption

A chemiluminescence method for assaying compounds containing primary amino groups using 1-cyano-2-substituted benz(f)- or naphth(f)-isoindole fluorescers is disclosed. The 1-cyano-2-substituted benz(f)- or naphth(f)-isoindole (CBI or CNI) is formed by reacting a compound containing a primary amino group with naphthalene-2-3-dicarboxaldehyde or anthracene-2,3-dicarboxaldehyde in the presence of cyanide ion. The reaction product of hydrogen peroxide with an oxalate ester is then combined with the CBI or CNI to form an analyte which exhibits chemiluminescence. A detector is used to measure the chemiluminescence emission from the chemiluminescence derivatized analytes. Compounds containing primary amino groups which may be assayed according to the present invention include primary amines, amino acids, peptides and catecholamines. The method can also be adapted to the analysis of trace amounts of cyanide ion and hydrogen peroxide.

Chemiluminescence method for assaying compounds containing primary amino

A drug delivery device retained in the stomach comprising a ring figure made from polymer(s) that may release a drug associated therewith over a controlled, predictable and extended period of time.

Drug delivery device which can be retained in the stomach for a

A diffusion cell for use in determining the absorption rate of a study substance through a permeable membrane. The cell includes a receptor chamber which contains receptor fluid to receive study substance absorbed through the membrane. The receptor chamber includes a fluid inlet and a fluid outlet. A rotary stirrer is situated adjacent the fluid outlet. The stirrer is rotated so as to rotate the receptor fluid in the receptor chamber in such manner that the fluid pressure is greater at the outlet than at the inlet, so that the stirrer defines a pump which pumps receptor fluid outwardly through the outlet, then through a detector, and then back into the receptor chamber through the inlet. The detector determines the concentration of study substance within the receptor fluid.

Methods and apparatus for determining the rate of movement of a study

A new class of substituted 2,3-naphthalenedicarboxaldehydes (NDA) is disclosed. Such compounds are of the formula: ##STR1## wherein one or more of R.sub.1 -R.sub.8 are various substituting groups. The above compounds react, in the presence of cyanide ion, with compounds containing primary amino groups to form adducts which exhibit a high fluorescent yield and thus are readily detected and measured by fluorometric assaying techniques.

Substituted 2,3-naphthalenedicarboxaldehydes

The instant invention is directed to a lipid osmotic pump, comprising:

Lipid osmotic pump

Certain novel cyclic ureas are disclosed herein as dermal penetration enhancers of drug absorption. Also disclosed herein are compositions, methods of treatment and processes for preparing said cyclic urea compounds.

Cyclic ureas as dermal penetration enhancers

The invention relates to the use of an acid anhydride incorporated as a latentiated catalyst in poly(ortho ester) and other polymers such that upon exposure to aqueous environments the acid anhydride generates the corresponding acid which catalyzes the matrix erosion. The releasing rate of a loaded drug substance incorporated into or surrounded by the poly(ortho ester) or other polymers can be controlled in that the drug is released as the poly(ortho ester)s or other polymer is eroded by action of the acid anhydride incorporated therein.

Acid anhydrides as rate controlling agent for the erosion of polymers

This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a liquid at room temperature but forms a semi-solid or gel at the body temperature in the body cavity.

Drug delivery system utilizing thermosetting gels

Present invention provides a unique drug delivery device for delivering drug by injection into a body. The drug delivery system comprises the drug and polymer which is a liquid at room temperature and a semi-solid or gel at the body temperature.

This invention describes the application of selected polymers as novel drug delivery systems which use the body temperature and pH to induce a liquid to gel transition of the polymer which contains a drug or therapeutic agent therein. The goal of such a delivery system is to achieve a greater degree of bioavailability or sustained concentration of a drug.

Ophthalmic drug delivery system utilizing thermosetting gels

This invention relates to a unique drug delivery system for application to the skin which drug delivery system is a liquid at room temperature, but when administered topically to the skin becomes a semi-solid or gel when warmed by the body.

Growing community of inventors

Lawrence, KS, United States of America

Takeru Higuchi