Mercian Corporation

Sanraku Incorporated

Sanraku-ocean Co., Ltd.

Other

Chugai Seiyaku Kabushiki Kaisha

Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Taisho Pharmaceutical Co., Ltd.

Takeo Yoshioka

Tomoyuki Ishikura

Yasuo Fukagawa

Rokuro Okamoto

Kunio Isshiki

Takashi Nakashima

Hiroshi Tone

Tomio Takeuchi

Kazuyuki Dobashi

Azuma Watanabe

Naoki Agata

Norio Shibamoto

Yasutaka Shimauchi

Hiroshi Tanaka

Naoki Matsumoto

Kaichiro Kominato

Shin-ichi Hirano

Hiroshi Tsunekawa

Tsutomu Sawa

Hiroyuki Kumagai

Takao Narita

Hitosi Agematu

Tadashi Fujii

Koji Takeda

Takurou Tsuruta

Kuniho Nakata

Mitsuyasu Okabe

Hiroshi Iguchi

Osamu Johdo

Noritaka Chida

Tadashi Terasawa

Hamao Umezawa

Masataka Shirai

Toshio Tsuchida

Kageaki Kouno

Yoshio Watanabe

Motoko Matsufuji

Akira Arisawa

Kenichi Yamamoto

Hiroyuki Chiba

Ryoichi Miyata

Hiroshi Nishida

Takashi Adachi

Toshikazu Oki

Sumio Umezawa

Donald W Kufe

Masaaki Ishizuka

Ralph R Weichselbaum

Toshiaki Miyake

Tomomi Ota

Kazuo Umezawa

Osamu Tsuchiya

Tomohiro Sameshima

Katsuro Kubo

Machiko Watanabe

Kohki Kiyoshima

Shunji Kageyama

Konomi Iguchi

Yasuo Okajima

Yasuyuki Kato

Noriaki Sakata

Kaoru Yamada

Kazuya Sakai

Miharu Maeda

Masaaki Ishizuki

Toshiyuki Mase

Kiyotomo Nakamura

Takuma Nakao

Corinne L Reimer

Koichiro Kominato

Sakino To-E

Toshihiko Kumamoto

Rei Kaneto

Tomoyuki Kioka

Yutaka Hara

Reijko Yamamoto

Provided are an isolated gene capable of participating in the production of L-homoglutamic acid, and a production system of L-homoglutamic acid by using this gene. The gene is derived from the genome of

Isolated nucleic acid encoding L-lysine: 2-oxoglutaric acid 6-aminotransferase

Gene participating in the production of homo-glutamic acid and utilization thereof

Disclosed are a crystalline form of anthracycline antibiotic having specific characteristic 2&thgr; values as measured by the X-ray diffraction method, and a process for producing the crystalline form. This process comprises the step of crystallization involving the combined use of a specific poor solvent for the antibiotic and a good solvent thereof. This crystalline form has excellent chemical and physical properties.

Crystalline anthracycline antibiotic and process for producing the same

Disclosed are a crystallizing method of doxorubicin hydrochloride from a doxorubicin hydrochloride-containing solution, particularly a method for carrying out the crystallization under a condition of 40&deg; C. or higher, and a doxorubicin hydrochloride crystalline aggregate having particularly an excellent solubility in water.

Crystallization of doxorubicin hydrochloride

A method for enhancing the efficacy of chemotherapy and/or radiation in the treatment of cancer in animals, particularly humans, is provided wherein certain isocoumarin derivatives which exhibit unique radiosensitization activity and/or chemopotentiation properties are employed in a combination treatment with ionizing radiation and/or chemotherapy.

Tumor radiosensitization and/or chemopotentiation using isocoumarin derivatives

Salicylamide derivatives represented by formulae ( ) and ( ); intermediates in the production thereof; a process for producing the same; and drugs containing the same as the active ingredient. The salicylamide derivatives represented by formulae ( ) and ( ) are useful as anti-inflammatory agents and immunosuppressive agents which exert an effect of inhibiting the activation of NF-&kgr;B with little side effects.

Salicylamide derivatives

A method for preparing at least one hydroxycholesterol chosen from the group consisting of 25-hydroxycholesterol, 17,25-dihydroxycholesterol and 25,26-dihydroxycholesterol by biological hydroxylation of cholesterol, and the aforementioned dihydroxycholesterols. In the above biological hydroxylation, a microorganism is used which has the abovementioned hydroxylation capacity and which belongs to the genus Amycolata and the genus Sphingomonas.

Dihydroxycholesterol hydroxylated at 17- and 25-positions

The present invention relates to a method in which daunomycin is eluted from a hydrophobic porous synthetic resin carrier onto which daunomycin is adsorbed from crude daunomycin with a buffered aqueous solution containing a water-miscible organic solvent to recover purified daunomycin. Daunomycin (daunorubicin) is purified efficiently.

Method of purifying daunomycin

This invention provides DNA fragments for efficiently preparing a protein having asymmetric hydrolase activity for 4-substituted 1,4-dihydropyridine derivatives, transformants obtained by using such a DNA fragment, and a process for preparing the aforesaid enzyme. Specifically, an isolated gene derived from the chromosome of and encoding a protein having asymmetric hydrolase activity for 4-substituted 1,4-dihydropyridine derivatives, plasmids having the aforesaid gene integrated thereinto, transformants obtained by using such a plasmid, and a process for preparing the aforesaid enzyme by using such a transformant are disclosed. A process for the enzymatic conversion of 4-substituted 1,4-dihydropyridine derivatives by using the aforesaid enzyme is also disclosed.

Gene encoding a protein having asymmetric hydrolase activity for 4-substituted 1,4-dihydropyridine derivatives and its expression product

Process for producing hydroxylated cholesterols and

Gene encoding a protein having symmetric hydrolase activity for

Optically active 1,4-dihydropyridine derivatives and process for the

A biological process for producing steroids hydroxylated at the 25-position thereof comprises adding steroids (excluding cholesterol) to the cells or culture liquid of a microorganism of the genus Amycolata or Sphingomonas capable of hydroxylating the steroids at the 25-position thereof to convert a hydrogen atom bonded to a carbon atom at the 25-position of each steroid into hydroxyl group. By this process, steroids(other than cholesterol) can be biologically hydroxylated at the 25-position by using microorganisms other than those of the genus Streptomyces.

Biological process for producing steroids hydroxylated at the 25-position

Chrysomycin derivative compounds and use as antitumor agents

Isocoumarin derivatives and use thereof in drugs

Growing community of inventors

Ayase, Japan

Takeo Yoshioka