Riken Corporation

Chiba University

Takeo Yoshikawa

Kenji Hashimoto

Motoko Maekawa

Eiji Hattori

Noriko Yoshimi

Takashi Futamura

Yoshimi Iwayama

Tetsuo Ohnishi

Mikael Landen

The invention of this application relates to a composition for growing hairs comprising, as an active ingredient, thiosulfuric acid or a salt thereof that has hair growing effects and has no side effects.

Hair growth composition

Methods of diagnosing, confirming a diagnosis of, and determining a predisposition for a bipolar disorder in a subject are provided. An amount of at least one of biomarker from the cerebrospinal fluid and/or serum of a subject is measured, for example, isocitric acid. The amount of the at least one biomarker can be compared with a control amount of the at least one biomarker in a corresponding sample collected from a subject without the bipolar disorder. An increase or decrease in the amount of the particular biomarker or biomarkers measured can be indicative that the subject has the bipolar disorder or a predisposition for the bipolar disorder. Methods of identifying a compound for preventing and/or treating a bipolar disorder are also provided based on the expression level of an isocitric acid dehydrogenase 3 alpha and/or beta-subunit gene, and/or based on one or more metabolite biomarker.

Methods of diagnosing bipolar disorders and screening for therapeutic compounds

The present invention relates to a method for diagnosing panic disorder, said method being based on the determination of the class of polymorphism of the short tandem repeat (STR) complex in the upstream region of human cholecystokinin gene. The polymorphic DNA comprises a DNA sequence, having a general formula (1):5'(GGAA)X(GGAG)(GGAA)(GGGA)GAG(AGAC)Y(GGAA)3&#x2032;&#x2003;&#x2003;(1)wherein X denotes a DNA sequence of SEQ ID NO: 1, Y denotes a DNA sequence of SEQ ID NO:2 and each of n1, n2, n3, n4, n5 and n6 denotes independently 0 or a positive integral number, whereby said DNA ranging from 363 to 399 base pairs in length. The invention also relates to an assay kit used for implementing said method.

Polymorphic DNAs and their use for diagnosis of susceptibility to panic disorder

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Wako, Japan

Takeo Yoshikawa