Kyowa Hakko Kogyo Co., Ltd.

Takeo Tanaka

Yuzuru Matsuda

Kenji Shibata

Motoo Yamasaki

Eiji Tsukuda

Toshiyuki Suzawa

Mayumi Yoshida

Tatsuhiro Ogawa

Keiichi Yano

Kazuo Yamaguchi

Katsuhiko Ando

Isao Kawamoto

Shigeto Kitamura

Shigeru Chiba

Hidemasa Kondo

Yoshikazu Morishita

Mika Makino

Toshihide Ikemura

Fumito Koizumi

Chieko Bando

Yutaka Saitoh

Tsutomu Agatsuma

Koji Yamada

Keiko Ochiai

Tetsuji Ohno

Youichi Uosaki

Shiro Soga

Hiroki Ishiguro

The present invention provides peptides represented by the following formula (A):wherein Q represents a physiologically active peptide moiety; X each represents the same or different &#x3b1;-amino acid residue; M represents Gly or Cys; m represents an integer of from 5 to 8; and n represents an integer of from 0 to 3, or their pharmaceutically acceptable salts thereof. The peptides of the present invention have higher stability and/or higher activity than physiologically active linear peptides to which no cyclic peptide is bonded.

Peptides

Endothelin-antagonizing peptide

The invention relates to biologically pure cultures of Streptomyces sp. RE-701 (FERM BP-3624) and Streptomyces sp. RE-629 (FERM BP-4126) that produce endothelin antagonistic peptides.

Strains of streptomyces producing endothelin antagonistic peptides

Physiologically active substance EI-2128-1

Provided is an Interleukin-1 production inhibiting compound represented by formula (I) ##STR1## wherein R denotes 4-methyl-1-pentenyl, 5-methyl-1,3-heptadienyl or 1-methylpentanyl.

Interleukin-1 production inhibiting compound

The present invention relates to EI-1941 compounds having interleukin-1 production inhibitory activity which are represented by the formula: ##STR1## wherein either of R.sup.1 and R.sup.2 is hydrogen and the other is hydroxy, or R.sup.1 and R.sup.2 together represent oxygen; and R.sup.3 is hydroxy and R.sup.4 is hydrogen, or R.sup.3 and R.sup.4 together represent --0--.

Physiologically active EI-1941 compounds

Peptides represented by the following formula (I): ##STR1## wherein A represents Asn or Asp; B represents His or Lys; and E represents Ala or Ser;

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Machida, Japan

Takeo Tanaka