Nitto-denko Corporation

Isis Pharmaceuticals, Inc.

Takeo Matsumura

Tatsuya Konishi

Vasulinga T Ravikumar

Gang Zhao

Raju K Kumar

Ayako Matsunawa

Kenjirou Mori

Cheiko Kitaura

Kenjiro Mori

The present invention provides solid support media for use in oligomer synthesis, methods of producing the media, and methods of using the media. In some embodiments, the processes of the invention comprise (a) providing an organic phase comprising an olefin monomer, a cross-linker, a functionalizing reagent and an initiator; and (b) contacting the organic phase with an aqueous phase under conditions of time and temperature effective to form the polymeric bead.

Polymeric beads for oligomer synthesis

The present invention provides a method of producing porous spherical particles, which includes suspension polymerization of a multifunctional monomer having two or more vinyl groups and a vinyl monomer having one vinyl group in an aqueous medium in the presence of a porogen and a distribution stabilizer, wherein the distribution stabilizer is polyvinyl alcohol having a saponification degree of 75 to 85 mol %. According to the method of the present invention, generation of particle agglomerates and large particles can be suppressed and porous spherical particles having a desired average particle size and a narrow particle size distribution can be conveniently produced.

Production method of porous spherical particles of vinyl polymer

Growing community of inventors

Miyagi, Japan

Takeo Matsumura