Hitachi Construction Machinery Co., Ltd.

The University of Tokyo

Tokyo Gas Company Limited

N K B Co., Ltd.

Takeo Iida

Hiroaki Suga

Toshimichi Ikeda

Hisao Taki

Mikio Aoyama

Etsuji Kosaka

Yasuhiko Haru

Shoji Yoshida

An object of the present invention is to provide molecules that bind to a target molecule in a pH dependent manner and a screening method for selecting such molecules. Provided is a screening method for selecting peptides that bind to a target molecule at a first pH and do not bind thereto at a second pH, including a step of preparing a peptide library in which each peptide contains at least one special amino acid that undergoes a pH-dependent change in the charge of the side chain thereof, a step of bringing the peptide library into contact with the target molecule and incubating them under the first pH condition and selecting peptides that bind to the target molecule, and a step of selecting, from the peptides which have bound to the target molecule, peptides that do not bind to the target molecule under the second pH condition.

Screening method for peptide binding to target molecule in pH-dependent manner

A lateral hole boring method whereby a lateral hole of a desired length is formed underground by repeatedly performing the following steps. A vertical hole is prepared, and a lateral hole boring apparatus equipped with a leading auger of a smaller length than the diameter of the vertical hole is lowered into the vertical hole to a predetermined position. The apparatus is manipulated from the ground level to advance and rotate the leading auger to bore a lateral hole. When the lateral hole has reached a predetermined length commensurate with the length of the leading auger, the advance movement of the leading auger is stopped, and the lateral hole boring apparatus is manipulated from the ground level to detach the leading auger therefrom, and is lifted above the vertical hole while leaving the leading auger in the lateral hole. A coupling auger of a smaller length than the diameter of the vertical hole is attached to the lateral hole boring apparatus outside the vertical hole, and the apparatus is lowered into the vertical hole again. Then, the lateral hole boring apparatus is manipulated from the ground level to couple the coupling auger to the leading auger left behind in the lateral hole.

Lateral hole boring method and apparatus

A process for fabricating display panels in which which comprises printing one surface of a pulp paper with a plurality of printed image layers exactly overlaying and aligned with each other bonding; the image bearing surface of the pulp paper bonded to one surface of a panel base; and removing the pulp paper so that the display image is transferred to and remains on the panel base.

Process for fabricating display panel

Growing community of inventors

Tokyo, Japan

Takeo Iida