Asahi Kasei Kogyo Kabushiki Kaisha

The Lion Dentrifice Co., Ltd.

Takeo Higashino

Yukio Suzuki

Daisuke Mochizuki

Tetsu Saito

Takehiko Sasahara

Shin-ichi Suzuki

Eisaku Hayashi

Described herein are pyrazolo[1,5-a]pyridine-3-carboxylic acid derivatives represented by the following formula (I): ##STR1## wherein R.sub.1 and R.sub.2 individually mean a hydrogen atom or a lower alkyl group, R.sub.3 denotes an azabicyclo group containing a tertiary nitrogen atom, and Y stands for --O-- or --NH--, or salts thereof. Their preparation process and serotonin receptor antagonists containing them as active ingredients are also described.

Pyrazolo[1,5-a]pyridine-3-carboxylic acid derivatives and their

Novel derivatives of 1-phenyl-1H-pyrazolo[3,4-d]pyrimidine substituted at the 4-position of the pyrimidine ring are provided. A typical example is 1-phenyl-1H-pyrazolo[3,4-d]pyrimidine-4-carbonitrile. The compounds exhibit excellent anti-carcinogenic activities as evidenced by the animal test with mice.

1-Phenyl-1H-pyrazolo[3,4-d]pyrimidine-4-carbonitrile and a method for

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Shizuoka, Japan

Takeo Higashino