Nisshin Flour Milling Co., Ltd.

Takeo Arai

Masashi Suzuki

Hiroaki Satoh

Haruhiko Kikuchi

Koichiro Hagihara

Setsuko Mino

Ruta Fukutomi

Masahiro Ueno

Yumiko Noguchi

Kohei Inomata

Haruko Eguchi

Ryuta Fukutomi

Sugure Taniguchi

Toru Hayakawa

Kazuhiko Yamada

An indazole compound having a piperazinyl moiety in the structure thereof, which is a 5-HT.sub.4 receptor agonist which is useful in the treatment of digestive tract disorders.

Indazole compound containing a monocyclic amine structure

Indazole derivatives having monocyclic amine

Diaminomethylidene derivatives

Pyrimidine derivatives

Compounds of formula (I) and pharmaceutically acceptable salts thereof are selective agonists for 5-HT.sub.4 receptors. ##STR1## wherein Ak is a C.sub.3 -C.sub.6 alkyl group, and R is a C.sub.2 -C.sub.6 alkyl group, a C.sub.3 -C.sub.6 alkenyl group, a C.sub.3 -C.sub.6 alkynyl group, a C.sub.3 -C.sub.7 cycloalkyl group or a C.sub.3 -C.sub.6 cycloalkylmethyl group.

5-HT.sub.4 receptor agonists

Diazabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, oxoalkyl, alkoxycarbonylalkyl, alkoxycarbonyl, acyl, dialkylaminoalkyl, hydroxyalkyl, haloalkyl, cyanoalkyl, heterocycloalkyl, aryl, heteroarylalkyl or arylalkyl, the aryl group and the aryl moiety being optionally substituted by alkoxy, nitro, alkyl, amino or halo;

Diazabicyclo derivatives

Growing community of inventors

Ohimachi, Japan

Takeo Arai