Astellas Pharma Gmbh

Takenori Kimura

Minoru Okada

Masahiko Hayakawa

Hiroyuki Kaizawa

Takashi Furutani

Kenichi Kawaguchi

Masakazu Imamura

Isao Kinoyama

Nobuaki Taniguchi

Noriyuki Kawano

Satoshi Miyamoto

Ryo Mizoguchi

Junya Ohmori

Noritaka Hamada

Makoto Kasai

Anytime obtained is uniform crystal of N-(4-fluorophenyl)-N'-phenyl-N&#x2033;-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine (compound A) and/or N,N&#x2032;-bis (4-fluorophenyl)-N&#x2033;-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine (compound B) as a medicament or a starting material for the preparation of the medicament, and provided are a fumarate of the compound A and/or the compound B having excellent stability and a novel crystal thereof. A salt of the compound A and/or the compound B with fumaric acid enables uniform crystal to be anytime obtained, and thus, it is a compound that is very useful as a medicament or a starting material for the preparation of the medicament having excellent stability.

Salt of 1,3,5-triazine-2,4,6-triamine derivative

The present invention relates to a novel N-phenyl-(2R,5S)dimethylpiperazine derivatives useful as antiandrogenic agent which exhibits a sufficient prostate gland reducing effect as compared with conventional compounds and are excellent in oral activity. The compound of the present application is useful in preventing or treating prostate cancer, benign prostatic hyperplasia, and the like. The present invention also provides a novel intermediate useful in producing the compound of the present invention.

N-phenyl-(2R,5S)dimethylpiperazine derivative

N-phenyl-(2R,5S) dimethylpiperazine derivative

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Takahagi-shi, Japan

Takenori Kimura