Sankyo Company, Limited

Takemichi Nakamura

Takafumi Kohama

Isao Kaneko

Takeshi Kagasaki

Keiichi Matsuda

Ryuzo Enokita

New compounds, which we have named the 'Leustroducsins' have the formula (I): ##STR1## in which R represents a 5-methylhexanoyloxy group, a 6-methyloctanoyloxy group or a 7-methyloctanoyloxy group, and salts thereof, and may be prepared by fermentation using a microorganism of the genus Streptomyces, especially a strain of the species Streptomyces platensis, such as strain SANK 60191 (FERM BP-3288). These compounds may be used for the treatment or prophylaxis of: adverse reactions resulting from cancer chemotherapy or radiotherapy; infections; cancer; cerebral dysfunction; and fungal infections.

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Tokyo, Japan

Takemichi Nakamura